Real-world outcomes of anti-PD1 antibodies in platinum-refractory, PD-L1-positive recurrent and/or metastatic non-small cell lung cancer, and its potential practical predictors: first report from Korean Cancer Study Group LU19-05
DC Field | Value | Language |
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dc.contributor.author | Park, J.H. | - |
dc.contributor.author | You, G.L. | - |
dc.contributor.author | Ahn, M.-J. | - |
dc.contributor.author | Kim, S.-W. | - |
dc.contributor.author | Hong, M.H. | - |
dc.contributor.author | Han, J.-Y. | - |
dc.contributor.author | Ock, C.-Y. | - |
dc.contributor.author | Lee, J.-S. | - |
dc.contributor.author | Oh, I.J. | - |
dc.contributor.author | Lee, S.Y. | - |
dc.contributor.author | Kim, C.H. | - |
dc.contributor.author | Min, Y.J. | - |
dc.contributor.author | Choi, Y.H. | - |
dc.contributor.author | Ryu, J.-S. | - |
dc.contributor.author | Park, S.H. | - |
dc.contributor.author | Ahn, H.K. | - |
dc.contributor.author | Shim, B.-Y. | - |
dc.contributor.author | Lee, K.H. | - |
dc.contributor.author | Lee, S.Y. | - |
dc.contributor.author | Kim, J.-S. | - |
dc.contributor.author | Yi, J. | - |
dc.contributor.author | Choi, S.K. | - |
dc.contributor.author | An, H. | - |
dc.contributor.author | Kang, J.H. | - |
dc.date.accessioned | 2021-07-06T02:40:04Z | - |
dc.date.available | 2021-07-06T02:40:04Z | - |
dc.date.created | 2021-02-09 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0171-5216 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81607 | - |
dc.description.abstract | Purpose: Although immune-checkpoint inhibitors have become a new therapeutic option for recurrent/metastatic non-small cell lung cancers (R/M-NSCLC), its clinical benefit in the real-world is still unclear. Methods: We investigated 1181 Korean patients with programmed death-1 ligand 1 (PD-L1)-positive [tumor proportion score (TPS) ≥ 10% by the SP263 assay or ≥ 50% by the 22C3 assay] R/M-NSCLC treated with pembrolizumab or nivolumab after failure of platinum-based chemotherapy. Results: The median age was 67 years, 13% of patients had ECOG-PS ≥ 2, and 27% were never-smokers. Adenocarcinoma was predominant (61%) and 18.1% harbored an EGFR activating mutation or ALK rearrangement. Pembrolizumab and nivolumab were administered to 51.3% and 48.7, respectively, and 42% received them beyond the third-line chemotherapy. Objective response rate (ORR) was 28.6%. Pembrolizumab group showed numerically higher ORR (30.7%) than the nivolumab group (26.4%), but it was comparable with that of the nivolumab group having PD-L1 TPS ≥ 50% (32.4%). Median progression-free survival (PFS) and overall survival (OS) were 2.9 (95% CI 0–27.9) and 10.7 months (95% CI 0–28.2), respectively. In multivariable analysis, concordance of TPS ≥ 50% in both PD-L1 assays and the development of immune-related adverse events (irAEs) were two significant predictors of better ORR, PFS, and OS. EGFR mutation could also predict significantly worse OS outcomes. Conclusion: The real-world benefit of later-line anti-PD1 antibodies was comparable to clinical trials in patients with R/M-NSCLC, although patients generally were more heavily pretreated and had poorer ECOG-PS. Concordantly high PD-L1 TPS ≥ 50% and development of irAE could independently predict better treatment outcomes, while EGFR mutation negatively affected OS. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | Journal of Cancer Research and Clinical Oncology | - |
dc.title | Real-world outcomes of anti-PD1 antibodies in platinum-refractory, PD-L1-positive recurrent and/or metastatic non-small cell lung cancer, and its potential practical predictors: first report from Korean Cancer Study Group LU19-05 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000613631200001 | - |
dc.identifier.doi | 10.1007/s00432-021-03527-4 | - |
dc.identifier.bibliographicCitation | Journal of Cancer Research and Clinical Oncology, v.147, no.8, pp.2459 - 2469 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85100098435 | - |
dc.citation.endPage | 2469 | - |
dc.citation.startPage | 2459 | - |
dc.citation.title | Journal of Cancer Research and Clinical Oncology | - |
dc.citation.volume | 147 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Ahn, H.K. | - |
dc.type.docType | Article in Press | - |
dc.subject.keywordAuthor | Biomarkers | - |
dc.subject.keywordAuthor | Immune-checkpoint inhibitor | - |
dc.subject.keywordAuthor | irAE | - |
dc.subject.keywordAuthor | Non-small cell lung cancer | - |
dc.subject.keywordAuthor | PD-L1 | - |
dc.subject.keywordAuthor | Real-world | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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