sFlt-1/PlGF ratio as a predictive and prognostic marker for preeclampsia
DC Field | Value | Language |
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dc.contributor.author | Jeon, Hae Rin | - |
dc.contributor.author | Jeong, Da Hoe | - |
dc.contributor.author | Lee, Jin Young | - |
dc.contributor.author | Woo, Eun Young | - |
dc.contributor.author | Shin, Gwi Taek | - |
dc.contributor.author | Kim, Suk-Young | - |
dc.date.accessioned | 2021-07-10T02:40:09Z | - |
dc.date.available | 2021-07-10T02:40:09Z | - |
dc.date.created | 2021-05-18 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1341-8076 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81649 | - |
dc.description.abstract | Objective: Preeclampsia is clinically unpredictable and associated with adverse outcomes. Pregnant women with suspected preeclampsia require intensive monitoring or hospitalization for elevated sFlt-1 (soluble fms-like tyrosine kinase-1) to PlGF (placental growth factor) ratios before symptoms arise. We aimed to determine the sFlt-1/PlGF ratio's usefulness in predicting adverse pregnancy outcomes in preeclampsia. Methods: From January 2017 to February 2019, we measured the sFlt-1/PlGF ratio in 73 singleton pregnant women suspected of preeclampsia and classified them into three groups: low-risk (sFlt-1/PlGF ratio < 38, n = 19), intermediate (38 <= ratio < 85, n = 9), and high-risk (ratio >= 85, n = 32). Results: Although the low- and high-risk groups both experienced weight gain during pregnancy, their body mass index (BMI) differed after pregnancy (p = 0.004). The number of women who had been taking antihypertensive medications for chronic hypertension since early pregnancy was higher in the low-risk group (31.6% vs. 22.2%, 6.7%). The gestational weeks at birth were lower in the high-risk group compared to that of the low-risk group (32.0 weeks vs. 35.79 weeks, p < 0.001). In the high-risk group, the average neonatal weight was significantly lighter (p = 0.021), and the period of stay in the neonatal intensive care unit was longer than that in the low-risk group (p = 0.003). Conclusion: The sFlt-1/PlGF ratio is a useful indicator of preeclampsia severity and can be utilized as a prognostic marker. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | - |
dc.title | sFlt-1/PlGF ratio as a predictive and prognostic marker for preeclampsia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000648927700001 | - |
dc.identifier.doi | 10.1111/jog.14815 | - |
dc.identifier.bibliographicCitation | JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, v.47, no.7, pp.2318 - 2323 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85105434697 | - |
dc.citation.endPage | 2323 | - |
dc.citation.startPage | 2318 | - |
dc.citation.title | JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | - |
dc.citation.volume | 47 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Jeon, Hae Rin | - |
dc.contributor.affiliatedAuthor | Jeong, Da Hoe | - |
dc.contributor.affiliatedAuthor | Lee, Jin Young | - |
dc.contributor.affiliatedAuthor | Woo, Eun Young | - |
dc.contributor.affiliatedAuthor | Shin, Gwi Taek | - |
dc.contributor.affiliatedAuthor | Kim, Suk-Young | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordAuthor | hypertension | - |
dc.subject.keywordAuthor | PlGF | - |
dc.subject.keywordAuthor | preeclampsia | - |
dc.subject.keywordAuthor | sFlt-1/PlGF ratio | - |
dc.subject.keywordAuthor | sFtl-1 | - |
dc.subject.keywordPlus | GROWTH-FACTOR RATIO | - |
dc.subject.keywordPlus | ADVERSE OUTCOMES | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | WOMEN | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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