Ruthenium(II)-curcumin liposome nanoparticles: Synthesis, characterization, and their effects against cervical cancer
DC Field | Value | Language |
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dc.contributor.author | Lakshmi, B.A. | - |
dc.contributor.author | Reddy, A.S. | - |
dc.contributor.author | Sangubotla, R. | - |
dc.contributor.author | Hong, Jong Wook | - |
dc.contributor.author | Kim, Sanghyo | - |
dc.date.accessioned | 2021-07-14T01:40:17Z | - |
dc.date.available | 2021-07-14T01:40:17Z | - |
dc.date.created | 2021-05-10 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81665 | - |
dc.description.abstract | Ruthenium complexes have increased the scope for improvement in current cancer treatment by replacing platinum-based drugs. However, to reduce metal-associated toxicity, a biocompatible flavonoid, such as curcumin, is indispensable, as it offers uncompensated therapeutic benefits through formation of complexes. In this study, we synthesized metal-based flavonoid complexes using ruthenium(II) and curcumin by adopting a convenient reflux reaction, represented as Ru-Cur complexes. These complexes were thoroughly characterized using 1H, 13C NMR, XPS, FT-IR, and UV–vis spectroscopy. As curcumin is sparingly soluble in water and has poor chemical stability, we loaded Ru-Cur complexes into liposomes and further formed nanoparticles (NPs) using the thin layer evaporation method. These were named Ru-Cur loaded liposome nanoparticles (RCLNPs). The effects of RCLNPs on cell proliferation was investigated using human cervical cancer cell lines (HeLa). These RCLNPs exhibited significant cytotoxicity in HeLa cells. The anticancer properties of RCLNPs were studied using reactive oxygen species (ROS), LDH, and MTT assays as well as live-dead staining. Nuclear damage studies of RCLNPs were performed in HeLa cells using the Hoechst staining assay. © 2021 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.title | Ruthenium(II)-curcumin liposome nanoparticles: Synthesis, characterization, and their effects against cervical cancer | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000670362700008 | - |
dc.identifier.doi | 10.1016/j.colsurfb.2021.111773 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.204 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85104913849 | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 204 | - |
dc.contributor.affiliatedAuthor | Lakshmi, B.A. | - |
dc.contributor.affiliatedAuthor | Reddy, A.S. | - |
dc.contributor.affiliatedAuthor | Sangubotla, R. | - |
dc.contributor.affiliatedAuthor | Kim, Sanghyo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Curcumin | - |
dc.subject.keywordAuthor | HeLa cells | - |
dc.subject.keywordAuthor | Liposome nanoparticles | - |
dc.subject.keywordAuthor | Metal-based flavonoid | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Ruthenium(II) | - |
dc.subject.keywordPlus | Biocompatibility | - |
dc.subject.keywordPlus | Cell culture | - |
dc.subject.keywordPlus | Cell proliferation | - |
dc.subject.keywordPlus | Chemical stability | - |
dc.subject.keywordPlus | Diseases | - |
dc.subject.keywordPlus | Drug delivery | - |
dc.subject.keywordPlus | Lanthanum compounds | - |
dc.subject.keywordPlus | Liposomes | - |
dc.subject.keywordPlus | Ruthenium compounds | - |
dc.subject.keywordPlus | Synthesis (chemical) | - |
dc.subject.keywordPlus | Cervical cancers | - |
dc.subject.keywordPlus | Curcumin | - |
dc.subject.keywordPlus | Flavonoid | - |
dc.subject.keywordPlus | HeLa cell | - |
dc.subject.keywordPlus | Liposome nanoparticle | - |
dc.subject.keywordPlus | Metal-based flavonoid | - |
dc.subject.keywordPlus | Nanoparticle synthesis | - |
dc.subject.keywordPlus | Reactive oxygen species | - |
dc.subject.keywordPlus | Ruthenium complexes | - |
dc.subject.keywordPlus | Ruthenium(II) | - |
dc.subject.keywordPlus | Nanoparticles | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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