Resveratrol enhances bone formation by modulating inflammation in the mouse periodontitis model
DC Field | Value | Language |
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dc.contributor.author | Adhikari, Nirpesh | - |
dc.contributor.author | Prasad Aryal, Yam | - |
dc.contributor.author | Jung, Jae-Kwang | - |
dc.contributor.author | Ha, Jung-Hong | - |
dc.contributor.author | Choi, So-Young | - |
dc.contributor.author | Kim, Ji-Youn | - |
dc.contributor.author | Lee, Tae-Hoon | - |
dc.contributor.author | Kim, Sang-Hyun | - |
dc.contributor.author | Yamamoto, Hitoshi | - |
dc.contributor.author | Suh, Jo-Young | - |
dc.contributor.author | An, Chang-Hyeon | - |
dc.contributor.author | Lee, Youngkyun | - |
dc.contributor.author | Sohn, Wern-Joo | - |
dc.contributor.author | An, Seo-Young | - |
dc.contributor.author | Kim, Jae-Young | - |
dc.date.accessioned | 2021-07-17T05:40:09Z | - |
dc.date.available | 2021-07-17T05:40:09Z | - |
dc.date.created | 2021-03-16 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0022-3484 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81700 | - |
dc.description.abstract | Objective: To evaluate the effect of resveratrol on periodontal bone regeneration after local delivery and to determine its effect on inflammatory mediators. Background: Resveratrol is considered an anti-inflammatory polyphenolic stilbene involved in the modulation of inflammation. Materials and Methods: Periodontitis was induced in mouse molars using a 5-day ligature model followed by the left second molar extraction and 50 µM resveratrol treatment for 1 and 2 weeks. We then examined specimens treated for 1 week histologically and with immunostaining. Microfocus-computed tomography (micro-CT) was used to examine the bone volume formation. Results: After 1 week of treatment, proinflammatory cytokine levels (TNF-alpha and IL6), cells exhibiting neutrophil and macrophage marker (MPO), cell proliferation marker (Ki67), and preosteoblastic marker (RUNX2) reactivity decreased in the resveratrol-treated specimens compared to the control group. In contrast, we observed a higher number of CD31-, F4/80-, and osteocalcin- (OCN-) positive cells in the resveratrol-treated specimens. After 2 weeks, micro-CT confirmed an increased bone mass in the region of the extraction socket in the resveratrol-treated group. Conclusion: After 1 week, the resveratrol-treated specimens revealed evidence of inflammation modulation compared to the control group. These data suggest that resveratrol not only affects inflammation control but also is useful for treating periodontitis-related tissue defects and bone regeneration. © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | Journal of Periodontal Research | - |
dc.title | Resveratrol enhances bone formation by modulating inflammation in the mouse periodontitis model | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000626094900001 | - |
dc.identifier.doi | 10.1111/jre.12870 | - |
dc.identifier.bibliographicCitation | Journal of Periodontal Research, v.56, no.4, pp.735 - 745 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85102169327 | - |
dc.citation.endPage | 745 | - |
dc.citation.startPage | 735 | - |
dc.citation.title | Journal of Periodontal Research | - |
dc.citation.volume | 56 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Kim, Ji-Youn | - |
dc.type.docType | Article in Press | - |
dc.subject.keywordAuthor | bone regeneration | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | periodontitis model | - |
dc.subject.keywordAuthor | tooth loss | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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