Expression pattern of tissue-resident memory T cells in cutaneous lupus erythematosus
DC Field | Value | Language |
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dc.contributor.author | Gu, Hyeon-Jung | - |
dc.contributor.author | Song, Shinyoung | - |
dc.contributor.author | Roh, Joo Young | - |
dc.contributor.author | Jung, YunJae | - |
dc.contributor.author | Kim, Hee Joo | - |
dc.date.accessioned | 2021-07-24T14:40:16Z | - |
dc.date.available | 2021-07-24T14:40:16Z | - |
dc.date.created | 2021-06-04 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81739 | - |
dc.description.abstract | Background: Tissue resident memory T cells (TRMs) persist long-term in peripheral tissues without recirculation, triggering an immediate protective inflammatory state upon the re-recognition of the antigen. Despite evidence incriminating the dysregulation of TRMs in autoimmune diseases, few studies have examined their expression in cutaneous lupus erythematosus (CLE). Objectives: We aimed to examine whether there are differences among TRM populations in CLE depending on different clinical conditions, such as the CLE subtype or association with systemic lupus erythematosus, and to determine the effect of type I interferon (IFN) on the development of TRMs in CLE. Methods: CLE disease activity was evaluated using the Cutaneous Lupus Erythematosus Disease Area and Severity Index. The expression of the TRM markers CD69 and CD103 in CLE lesions was evaluated by immunofluorescence. Flow cytometry was performed on peripheral blood mononuclear cells after IFNα treatment. Results: The number of TRMs expressing either CD69 or CD103 was significantly higher in CLE lesions than in control skin; however, it was not significantly different between discoid lupus erythematosus and subacute CLE, or dependent on the presence of concomitant systemic lupus. Lesional severity was not correlated with an increase in TRMs in CLE. IFNα treatment induced a conspicuous increase in CD69 expression in skin-homing T cells, more profoundly in CD4+ T cells than in CD8+ T cells. Conclusions: Skin TRMs, either CD69 or CD103-positive cells, showed increased levels in the lesional skin of CLE, and IFNα increased the expression of CD69 in T cells. © The Author(s) 2021. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.relation.isPartOf | LUPUS | - |
dc.title | Expression pattern of tissue-resident memory T cells in cutaneous lupus erythematosus | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000652871000001 | - |
dc.identifier.doi | 10.1177/09612033211017218 | - |
dc.identifier.bibliographicCitation | LUPUS, v.30, no.9, pp.1427 - 1437 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85106438194 | - |
dc.citation.endPage | 1437 | - |
dc.citation.startPage | 1427 | - |
dc.citation.title | LUPUS | - |
dc.citation.volume | 30 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Gu, Hyeon-Jung | - |
dc.contributor.affiliatedAuthor | Song, Shinyoung | - |
dc.contributor.affiliatedAuthor | Roh, Joo Young | - |
dc.contributor.affiliatedAuthor | Jung, YunJae | - |
dc.contributor.affiliatedAuthor | Kim, Hee Joo | - |
dc.type.docType | Article in Press | - |
dc.subject.keywordAuthor | cutaneous lupus erythematosus | - |
dc.subject.keywordAuthor | discoid lupus erythematosus | - |
dc.subject.keywordAuthor | subacute cutaneous lupus erythematosus | - |
dc.subject.keywordAuthor | Tissue-resident memory T cell | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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