Lenalidomide for anemia correction in lower-risk del(5q) myelodysplastic syndrome patients of Asian ethnicity
DC Field | Value | Language |
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dc.contributor.author | Junshik Hong | - |
dc.contributor.author | Yoo Jin Lee | - |
dc.contributor.author | Sung Hwa Bae | - |
dc.contributor.author | Jun Ho Yi | - |
dc.contributor.author | Sungwoo Park | - |
dc.contributor.author | Myung Hee Chang | - |
dc.contributor.author | Young Hoon Park | - |
dc.contributor.author | Shin Young Hyun | - |
dc.contributor.author | Joo Seop Chung | - |
dc.contributor.author | Ji Eun Jang | - |
dc.contributor.author | Joo Young Jung | - |
dc.contributor.author | So Yeon Jeon | - |
dc.contributor.author | Seo-Young Song | - |
dc.contributor.author | Hawk Kim | - |
dc.contributor.author | Dae Sik Kim | - |
dc.contributor.author | Sung Hyun Kim | - |
dc.contributor.author | Min Kyoung Kim | - |
dc.contributor.author | Sang Hoon Han | - |
dc.contributor.author | Seonyang Park | - |
dc.contributor.author | Yoo-Jin Kim | - |
dc.contributor.author | Je-Hwan Lee | - |
dc.date.accessioned | 2021-07-28T00:41:33Z | - |
dc.date.available | 2021-07-28T00:41:33Z | - |
dc.date.created | 2021-07-01 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 2287-979X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81767 | - |
dc.description.abstract | Background To estimate real-world outcomes in East Asian populations, we conducted a nationwide retrospective analysis of the efficacy and safety of lenalidomide for del(5q) myelodysplastic syndrome (MDS) patients with transfusion-dependent anemia in Korea. Methods Patients aged ≥19 years who had received lenalidomide for the treatment of lower-risk, red blood cell (RBC) transfusion-dependent del(5q) MDS were selected. A filled case report form (CRF) with information from electronic medical records was requested from members of the acute myeloid leukemia (AML)/MDS Working Party of the Korean Society of Hematology. All the CRFs were gathered and analyzed. Results A total of 31 patients were included in this study. Of 28 evaluable patients, 19 (67.9%) achieved RBC transfusion independence (RBC-TI). Female sex and the development of thrombocytopenia during treatment were associated with achieving RBC-TI. The most common non-hematologic toxicities were pruritus, fatigue, and rashes. All non-hematologic toxicities of grades ≥3 were limited to rash (12.9%) and pruritus (6.5%). Dose reduction was required in 15 of the 19 responders (78.9%). The most common final stable dosing schedule for the responders was 5 mg once every other day (31.6%). Conclusion Lenalidomide efficacy and tolerability were similar in the Asian del(5q) MDS patients and western patients. Dose reduction during treatment was common, but it was not associated with inferior outcomes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한혈액학회 | - |
dc.relation.isPartOf | Blood Research | - |
dc.title | Lenalidomide for anemia correction in lower-risk del(5q) myelodysplastic syndrome patients of Asian ethnicity | - |
dc.title.alternative | Lenalidomide for anemia correction in lower-risk del(5q) myelodysplastic syndrome patients of Asian ethnicity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000668684400008 | - |
dc.identifier.doi | 10.5045/br.2021.2021086 | - |
dc.identifier.bibliographicCitation | Blood Research, v.56, no.2, pp.102 - 108 | - |
dc.identifier.kciid | ART002728065 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85110308856 | - |
dc.citation.endPage | 108 | - |
dc.citation.startPage | 102 | - |
dc.citation.title | Blood Research | - |
dc.citation.volume | 56 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Hawk Kim | - |
dc.subject.keywordAuthor | 5q deletion syndrome | - |
dc.subject.keywordAuthor | Myelodysplastic syndrome | - |
dc.subject.keywordAuthor | Lenalidomide | - |
dc.subject.keywordAuthor | Anemia | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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