Schisandrol A Exhibits Estrogenic Activity via Estrogen Receptor alpha-Dependent Signaling Pathway in Estrogen Receptor-Positive Breast Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Kim, Young-Mi | - |
dc.contributor.author | Chin, Young-Won | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.accessioned | 2021-07-30T00:41:08Z | - |
dc.date.available | 2021-07-30T00:41:08Z | - |
dc.date.created | 2021-07-30 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81776 | - |
dc.description.abstract | The aim of this study was to examine the estrogen-like effects of gentiopicroside, macelignan, gamma-mangostin, and three lignans (schisandrol A, schisandrol B, and schisandrin C), and their possible mechanism of action. Their effects on the proliferation of the estrogen receptor (ER)-positive breast cancer cell line (MCF-7) were evaluated using Ez-Cytox reagents. The expression of extracellular signal-regulated kinase (ERK), phosphatidylinositol 3-kinase (PI3K), AKT, and estrogen receptor alpha (ER alpha) was measured by performing Western blot analysis. 17 beta-estradiol (E2), also known as estradiol, is an estrogen steroid and was used as a positive control. ICI 182,780 (ICI), an ER antagonist, was used to block the ER function. Our results showed that, except for gentiopicroside, all the compounds promoted proliferation of MCF-7 cells, with schisandrol A being the most effective; this effect was better than that of E2 and was mitigated by ICI. Consistently, the expression of ERK, PI3K, AKT, and ER alpha increased following treatment with schisandrol A; this effect was slightly better than that of E2 and was mitigated by ICI. Taken together, the ER alpha induction via the PI3K/AKT and ERK signaling pathways may be a potential mechanism underlying the estrogen-like effects of schisandrol A. This study provides an experimental basis for the application of schisandrol A as a phytoestrogen for the prevention of menopausal symptoms. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | PHARMACEUTICS | - |
dc.title | Schisandrol A Exhibits Estrogenic Activity via Estrogen Receptor alpha-Dependent Signaling Pathway in Estrogen Receptor-Positive Breast Cancer Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000676155000001 | - |
dc.identifier.doi | 10.3390/pharmaceutics13071082 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICS, v.13, no.7 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85111332464 | - |
dc.citation.title | PHARMACEUTICS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | phytoestrogens | - |
dc.subject.keywordAuthor | estrogen receptor | - |
dc.subject.keywordAuthor | schisandrol A | - |
dc.subject.keywordPlus | E-SCREEN ASSAY | - |
dc.subject.keywordPlus | ICI 182,780 | - |
dc.subject.keywordPlus | MCF-7 | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | PHYTOESTROGENS | - |
dc.subject.keywordPlus | LIGNANS | - |
dc.subject.keywordPlus | LINE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ERK | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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