Chemical-Mediated Targeted Protein Degradation in Neurodegenerative Diseases
DC Field | Value | Language |
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dc.contributor.author | Hyun, Soonsil | - |
dc.contributor.author | Shin, Dongyun | - |
dc.date.accessioned | 2021-07-30T00:41:26Z | - |
dc.date.available | 2021-07-30T00:41:26Z | - |
dc.date.created | 2021-07-12 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 0024-3019 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81779 | - |
dc.description.abstract | Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease, are a class of diseases that lead to dysfunction of cognition and mobility. Aggregates of misfolded proteins such as β-amyloid, tau, α-synuclein, and polyglutamates are known to be among the main causes of neurodegenerative diseases; however, they are considered to be some of the most challenging drug targets because they cannot be modulated by conventional small-molecule agents. Recently, the degradation of target proteins by small molecules has emerged as a new therapeutic modality and has garnered the interest of the researchers in the pharmaceutical industry. Bifunctional molecules that recruit target proteins to a cellular protein degradation machinery, such as the ubiquitin–proteasome system and autophagy–lysosome pathway, have been designed. The representative targeted protein degradation technologies include molecular glues, proteolysis-targeting chimeras, hydrophobic tagging, autophagy-targeting chimeras, and autophagosome-tethering compounds. Although these modalities have been shown to degrade many disease-related proteins, such technologies are expected to be potentially important for neurogenerative diseases caused by protein aggregation. Herein, we review the recent progress in chemical-mediated targeted protein degradation toward the discovery of drugs for neurogenerative diseases. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | LIFE-BASEL | - |
dc.title | Chemical-Mediated Targeted Protein Degradation in Neurodegenerative Diseases | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000676397000001 | - |
dc.identifier.doi | 10.3390/life11070607 | - |
dc.identifier.bibliographicCitation | LIFE-BASEL, v.11, no.7 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85109132273 | - |
dc.citation.title | LIFE-BASEL | - |
dc.citation.volume | 11 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Hyun, Soonsil | - |
dc.contributor.affiliatedAuthor | Shin, Dongyun | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | Drug design | - |
dc.subject.keywordAuthor | Neurodegenerative disease | - |
dc.subject.keywordAuthor | Protac | - |
dc.subject.keywordAuthor | Protein degradation | - |
dc.subject.keywordAuthor | Soonsil Hyun and Dongyun Shin | - |
dc.subject.keywordAuthor | Ubiquitin-proteasome system | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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