A Flounder Fish Peptide Shows Anti-Hypertensive Effects by Suppressing the Renin-Angiotensin-Aldosterone System and Endothelin-1
DC Field | Value | Language |
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dc.contributor.author | Rahmdel, Mohamad | - |
dc.contributor.author | Cho, Sang Min | - |
dc.contributor.author | Jeon, You-Jin | - |
dc.contributor.author | Lee, Dae Ho | - |
dc.date.accessioned | 2021-08-23T00:40:44Z | - |
dc.date.available | 2021-08-23T00:40:44Z | - |
dc.date.created | 2021-08-23 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0929-8665 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81906 | - |
dc.description.abstract | Background: Many fishes have been known for their good nutritional effects especially in the cardiovascular aspect. Some specific fish peptides have anti-hypertensive effects. Objective: In the present study, we hypothesized that the hexapeptide (MEVFVP) from flounder fish muscle can be a potent antihypertensive peptide, therefore, decided to perform this experiment. Methods: The peptide MEVFVP from flounder fish muscle (40 mg/kg) and vehicle were administered per os to spontaneously hypertensive rats (SHRs) (SHR-M and SHR-C, respectively). Additionally, plasma MEVFVP was measured serially before and after its oral administration to Sprague Dawley rats. Results: Blood pressures (BPs), especially systolic BP, in SHR rats were decreased around 3-6 hours after MEVFVP administration. Compared with SHR-C rats, endothelin-1 (ET-1) mRNA expression in multiple tissues, and plasma levels of ET-1, angiotensin II, and aldosterone were lower in SHR-M rats, whereas the phosphorylation of AMP-activated protein kinase (AMPK) was increased in the kidney of SHR-M rats. The administered peptide was not detected in rat plasma, while ex vivo incubation of the peptide in rat plasma caused its rapid degradation within minutes. Conclusion: Our results show that the MEVFVP has an antihypertensive effect by regulating renin-angiotensin-aldosterone system, ET-1 and AMPK despite its limited bioavailability. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BENTHAM SCIENCE PUBL LTD | - |
dc.relation.isPartOf | PROTEIN AND PEPTIDE LETTERS | - |
dc.title | A Flounder Fish Peptide Shows Anti-Hypertensive Effects by Suppressing the Renin-Angiotensin-Aldosterone System and Endothelin-1 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000683897300002 | - |
dc.identifier.doi | 10.2174/0929866528666210211142105 | - |
dc.identifier.bibliographicCitation | PROTEIN AND PEPTIDE LETTERS, v.28, no.7, pp.831 - 840 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85115040288 | - |
dc.citation.endPage | 840 | - |
dc.citation.startPage | 831 | - |
dc.citation.title | PROTEIN AND PEPTIDE LETTERS | - |
dc.citation.volume | 28 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Rahmdel, Mohamad | - |
dc.contributor.affiliatedAuthor | Cho, Sang Min | - |
dc.contributor.affiliatedAuthor | Lee, Dae Ho | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Spontaneously hypertensive rat | - |
dc.subject.keywordAuthor | antihypertensive agent | - |
dc.subject.keywordAuthor | endothelin-1 | - |
dc.subject.keywordAuthor | renin-angiotensin system | - |
dc.subject.keywordAuthor | aldosterone | - |
dc.subject.keywordAuthor | an-giotensin II | - |
dc.subject.keywordAuthor | SHR | - |
dc.subject.keywordPlus | ENZYME INHIBITORY PEPTIDES | - |
dc.subject.keywordPlus | CONVERTING-ENZYME | - |
dc.subject.keywordPlus | BIOACTIVE PEPTIDES | - |
dc.subject.keywordPlus | HYDROLYSATE | - |
dc.subject.keywordPlus | PURIFICATION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | MUSCLE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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