Metabolic Acidosis Is an Independent Risk Factor of Renal Progression in Korean Chronic Kidney Disease Patients: The KNOW-CKD Study Results
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyo Jin | - |
dc.contributor.author | Ryu, Hyunjin | - |
dc.contributor.author | Kang, Eunjeong | - |
dc.contributor.author | Kang, Minjung | - |
dc.contributor.author | Han, Miyeun | - |
dc.contributor.author | Song, Sang Heon | - |
dc.contributor.author | Lee, Joongyub | - |
dc.contributor.author | Jung, Ji Yong | - |
dc.contributor.author | Lee, Kyu-Beck | - |
dc.contributor.author | Sung, Suah | - |
dc.contributor.author | Seong, Eun Young | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.date.accessioned | 2021-08-23T00:41:12Z | - |
dc.date.available | 2021-08-23T00:41:12Z | - |
dc.date.created | 2021-08-23 | - |
dc.date.issued | 2021-07-29 | - |
dc.identifier.issn | 2296-858X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81911 | - |
dc.description.abstract | Background: We aimed to evaluate serum bicarbonate as a risk factor for renal progression, cardiovascular events, and mortality in Korean CKD patients. Methods: We analyzed 1,808 participants from a Korean CKD cohort whose serum bicarbonate levels were measured at enrollment. Serum bicarbonate levels were categorized as low, lower normal, higher normal, and high (total carbon dioxide <22, 22-26, 26.1-29.9, and >= 30 mmol/L, respectively) groups. Metabolic acidosis was defined as a serum bicarbonate level <22 mmol/L. The primary outcome was renal events defined as doubling of serum creatinine, 50% reduction of eGFR from the baseline values, or development of end-stage kidney disease. The secondary outcome consisted of cardiovascular events and death. In addition, patients whose eGFR values were measured more than three times during the follow-up period were analyzed for eGFR decline. The rapid decline in eGFR was defined as lower than the median value of the eGFR slope. Results: The mean serum bicarbonate level was 25.7 +/- 3.7 mmol/L and 240 (13.2%) patients had metabolic acidosis. During the follow-up period of 55.2 +/- 24.1 months, 545 (30.9%) patients developed renal events and 187 (10.6%) patients developed a composite of cardiovascular events and death. After adjustment, the low serum bicarbonate group experienced 1.27 times more renal events than the lower normal bicarbonate group [hazard ratio (HR): 1.27; 95% CI: 1.01-1.60, P = 0.043]. There was no significant association between the bicarbonate groups and the composite outcome of cardiovascular events and death. The low bicarbonate group showed a significantly rapid decline in eGFR [odds ratio (OR): 2.12; 95% CI: 1.39-3.22, P < 0.001] compared to the lower normal bicarbonate group. Conclusions: Metabolic acidosis was significantly associated with increased renal events and a rapid decline in renal function in Korean predialysis CKD patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.relation.isPartOf | FRONTIERS IN MEDICINE | - |
dc.title | Metabolic Acidosis Is an Independent Risk Factor of Renal Progression in Korean Chronic Kidney Disease Patients: The KNOW-CKD Study Results | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000684669900001 | - |
dc.identifier.doi | 10.3389/fmed.2021.707588 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN MEDICINE, v.8 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85112420801 | - |
dc.citation.title | FRONTIERS IN MEDICINE | - |
dc.citation.volume | 8 | - |
dc.contributor.affiliatedAuthor | Jung, Ji Yong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | metabolic acidosis | - |
dc.subject.keywordAuthor | serum bicarbonate | - |
dc.subject.keywordAuthor | chronic kidney disease | - |
dc.subject.keywordAuthor | renal progression | - |
dc.subject.keywordAuthor | renal function decline | - |
dc.subject.keywordPlus | SERUM BICARBONATE LEVELS | - |
dc.subject.keywordPlus | FUNCTION DECLINE | - |
dc.subject.keywordPlus | BASE-BALANCE | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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