Inflammation Alters Relationship Between High-Density Lipoprotein Cholesterol and Cardiovascular Risk in Patients With Chronic Kidney Disease: Results From KNOW-CKD
DC Field | Value | Language |
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dc.contributor.author | Kim, Jae Young | - |
dc.contributor.author | Park, Jung Tak | - |
dc.contributor.author | Kim, Hyung Woo | - |
dc.contributor.author | Chang, Tae-Ik | - |
dc.contributor.author | Kang, Ea Wha | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.contributor.author | Lee, Joongyub | - |
dc.contributor.author | Chung, Wookyung | - |
dc.contributor.author | Kim, Yong-Soo | - |
dc.contributor.author | Kim, Soo Wan | - |
dc.contributor.author | Yoo, Tae-Hyun | - |
dc.contributor.author | Kang, Shin-Wook | - |
dc.contributor.author | Han, Seung Hyeok | - |
dc.date.accessioned | 2021-08-27T02:40:27Z | - |
dc.date.available | 2021-08-27T02:40:27Z | - |
dc.date.created | 2021-08-27 | - |
dc.date.issued | 2021-08-17 | - |
dc.identifier.issn | 2047-9980 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81929 | - |
dc.description.abstract | BACKGROUND: The function of high-density lipoprotein can change from protective to proatherosclerotic under inflammatory conditions. Herein, we studied whether inflammation could modify the relationship between high-density lipoprotein level and risk of adverse outcomes in patients with chronic kidney disease . METHODS AND RESULTS: In total, 1864 patients from the prospective KNOW-CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease) were enrolled. The main predictor was high-density lipoprotein cholesterol (HDL-C) level. Presence of inflammation was defined by hs-CRP (high-sensitivity C-reactive protein) level of >= 1.0 mg/L. The primary outcome was extended major adverse cardiovascular events. During 9231.2 person-years of follow-up, overall incidence of the primary outcome was 15.8 per 1000 person-years. In multivariable Cox analysis after adjusting for confounders, HDL-C level was not associated with the primary outcome. There was a significant interaction between the inflammatory status and HDL-C for risk of extended major adverse cardiovascular events (P=0.003). In patients without inflammation, the hazard ratios (HRs) (95% CIs) for HDL-C levels <40, 50 to 59, and >= 60 mg/dL were 1.10 (0.50-1.82), 0.95 (0.50-1.82), and 0.42 (0.19-0.95), respectively, compared with HDL-C of 40 to 49 mg/dL. However, the significant association for HDL-C >= 60 mg/dL was not seen after Bonferroni correction. In patients with inflammation, we observed a trend toward increased risk of extended major adverse cardiovascular events in higher HDL-C groups (HRs [95% CIs], 0.73 [0.37-1.43], 1.24 [0.59-2.61], and 1.56 [0.71-3.45], respectively), but without statistical significance. CONCLUSIONS: The association between HDL-C level and adverse cardiovascular outcomes showed reverse trends based on inflammation status in Korean patients with chronic kidney disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN HEART ASSOCIATION | - |
dc.title | Inflammation Alters Relationship Between High-Density Lipoprotein Cholesterol and Cardiovascular Risk in Patients With Chronic Kidney Disease: Results From KNOW-CKD | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000685396200023 | - |
dc.identifier.doi | 10.1161/JAHA.120.021731 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN HEART ASSOCIATION, v.10, no.16 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85113289002 | - |
dc.citation.title | JOURNAL OF THE AMERICAN HEART ASSOCIATION | - |
dc.citation.volume | 10 | - |
dc.citation.number | 16 | - |
dc.contributor.affiliatedAuthor | Chung, Wookyung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | chronic kidney disease | - |
dc.subject.keywordAuthor | high-density lipoprotein cholesterol | - |
dc.subject.keywordAuthor | high-sensitivity C-reactive protein | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | major adverse cardiovascular events | - |
dc.subject.keywordPlus | ISCHEMIC-HEART-DISEASE | - |
dc.subject.keywordPlus | HDL CHOLESTEROL | - |
dc.subject.keywordPlus | LDL CHOLESTEROL | - |
dc.subject.keywordPlus | ELEVATED HDL | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | EVENTS | - |
dc.subject.keywordPlus | UREMIA | - |
dc.subject.keywordPlus | WOMEN | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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