Drug-induced Parkinsonism versus Idiopathic Parkinson Disease: Utility of Nigrosome 1 with 3-T Imaging
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sung, Young Hee | - |
dc.contributor.author | Noh, Young | - |
dc.contributor.author | Lee, Jongho | - |
dc.contributor.author | Kim, Eung Yeop | - |
dc.date.available | 2020-02-28T01:44:14Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-06 | - |
dc.identifier.issn | 0033-8419 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8192 | - |
dc.description.abstract | Purpose: To explore the utility of nigrosome 1 with 3-T magnetic resonance (MR) imaging to differentiate idiopathic Parkinson disease (IPD) from drug-induced parkinsonism (DIP). Materials and Methods: The institutional review board approved this study, and participants gave informed consent. This study enrolled patients with DIP (n = 20) and IPD (n = 29) who underwent N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl) nortropane (F-18-FP-CIT) positron emission tomography (PET) and healthy participants (n = 20). All participants underwent 0.5 x 0.5 x 1.0 mm(3) oblique axial three-dimensional multiecho-data image combination imaging to view the nigrosome 1 with 3-T imaging. Two reviewers independently assessed the nigrosome 1 without clinical information. DIP was diagnosed when no abnormality was seen at F-18-FP-CIT PET. Diagnostic sensitivity, specificity, and accuracy of the nigrosome 1 imaging were evaluated between the IPD and DIP patients and between the IPD patients and healthy participants. Interrater agreement was assessed with Cohen k. Results: Both reviewers agreed in 63 of 69 participants (91.3%) for the presence of any abnormality on either side of the nigrosome 1 (k = 0.825). Findings in all 29 IPD patients (100%) and three of 20 DIP patients (15%) were rated as abnormal and in 17 of 20 DIP patients (85%) they were interpreted as normal on the basis of imaging of the nitgrosome 1 (sensitivity, 100% (29 of 29); specificity, 85.0% (17 of 20); accuracy, 93.9% (46 of 49) between IPD and DIP patients). Findings in 3 of 20 healthy participants (15.0%) were interpreted as abnormal on the basis of imaging the nigrosome 1 while in the other 17 of 20 healthy participants (85.0%) they were rated as normal (sensitivity, 100% [29 of 29]; specificity, 85.0% [17 of 20]; accuracy, 93.9% [46 of 49] between IPD patients and healthy participants [k = 0.831]). Conclusion: The imaging of nigrosome 1 with 3-T imaging can differentiate DIP from IPD with high accuracy and may help to screen patients who need dopamine transporter imaging in those suspected of having DIP. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | RADIOLOGICAL SOC NORTH AMERICA | - |
dc.relation.isPartOf | RADIOLOGY | - |
dc.subject | SUBSTANTIA-NIGRA | - |
dc.subject | RATING-SCALE | - |
dc.subject | DISORDERS | - |
dc.subject | DIAGNOSIS | - |
dc.subject | SPECT | - |
dc.subject | PD | - |
dc.title | Drug-induced Parkinsonism versus Idiopathic Parkinson Disease: Utility of Nigrosome 1 with 3-T Imaging | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000378719700023 | - |
dc.identifier.doi | 10.1148/radiol.2015151466 | - |
dc.identifier.bibliographicCitation | RADIOLOGY, v.279, no.3, pp.849 - 858 | - |
dc.identifier.scopusid | 2-s2.0-85011582881 | - |
dc.citation.endPage | 858 | - |
dc.citation.startPage | 849 | - |
dc.citation.title | RADIOLOGY | - |
dc.citation.volume | 279 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Sung, Young Hee | - |
dc.contributor.affiliatedAuthor | Noh, Young | - |
dc.contributor.affiliatedAuthor | Kim, Eung Yeop | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SUBSTANTIA-NIGRA | - |
dc.subject.keywordPlus | RATING-SCALE | - |
dc.subject.keywordPlus | DISORDERS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | SPECT | - |
dc.subject.keywordPlus | PD | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.