In Situ Biosynthesis of a Metal Nanoparticle Encapsulated in Alginate Gel for Imageable Drug-Delivery System
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Moon Il | - |
dc.contributor.author | Park, Chan Yeong | - |
dc.contributor.author | Seo, Ji Min | - |
dc.contributor.author | Kang, Kyoung Suk | - |
dc.contributor.author | Park, Ki Soo | - |
dc.contributor.author | Kang, Jongeun | - |
dc.contributor.author | Hong, Kwan Soo | - |
dc.contributor.author | Choi, Yoojin | - |
dc.contributor.author | Lee, Sang Yup | - |
dc.contributor.author | Park, Jong Pil | - |
dc.contributor.author | Park, Hyun Gyu | - |
dc.contributor.author | Park, Tae Jung | - |
dc.date.accessioned | 2021-08-30T00:40:53Z | - |
dc.date.available | 2021-08-30T00:40:53Z | - |
dc.date.created | 2021-08-23 | - |
dc.date.issued | 2021-08-11 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81948 | - |
dc.description.abstract | Development of drug-delivery systems that allow simultaneous in vivo imaging has gained much interest. We report a novel strategy to encapsulate metal nanoparticles (NPs) within alginate gel for in vivo imaging. The cell lysate of recombinant Escherichia coli strain, expressing Arabidopsis thaliana phytochelatin synthase and Pseudomonas putida metallothionein genes, was encapsulated within the alginate gel. Incubation of alginate gel with metal ion precursors followed by UV irradiation resulted in the synthesis of high concentrations of metal NPs, such as Au, Ag, CdSe, and EuSe NPs, within the gel. The alginate gel with metal NPs was used as a drug-delivery system by further co-encapsulating doxorubicin and rifampicin, the release of which was made to be pH-dependent. This system can be conveniently and safely used for in vitro and in vivo bioimaging, enabled by the metal NPs formed within the gel matrix without using toxic reducing reagents or surfactants. © XXX American Chemical Society. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ACS APPLIED MATERIALS & INTERFACES | - |
dc.title | In Situ Biosynthesis of a Metal Nanoparticle Encapsulated in Alginate Gel for Imageable Drug-Delivery System | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000685245800004 | - |
dc.identifier.doi | 10.1021/acsami.1c02286 | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.13, no.31, pp.36697 - 36708 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85112565355 | - |
dc.citation.endPage | 36708 | - |
dc.citation.startPage | 36697 | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 13 | - |
dc.citation.number | 31 | - |
dc.contributor.affiliatedAuthor | Kim, Moon Il | - |
dc.type.docType | Article in Press | - |
dc.subject.keywordAuthor | Alginate gel | - |
dc.subject.keywordAuthor | Biogenic metal nanoparticle | - |
dc.subject.keywordAuthor | Bioimaging | - |
dc.subject.keywordAuthor | Drug-delivery system | - |
dc.subject.keywordAuthor | In situ synthesis | - |
dc.subject.keywordPlus | Alginate | - |
dc.subject.keywordPlus | Biochemistry | - |
dc.subject.keywordPlus | Cadmium compounds | - |
dc.subject.keywordPlus | Controlled drug delivery | - |
dc.subject.keywordPlus | Escherichia coli | - |
dc.subject.keywordPlus | Europium compounds | - |
dc.subject.keywordPlus | Gold compounds | - |
dc.subject.keywordPlus | II-VI semiconductors | - |
dc.subject.keywordPlus | Irradiation | - |
dc.subject.keywordPlus | Metal ions | - |
dc.subject.keywordPlus | Metals | - |
dc.subject.keywordPlus | Plants (botany) | - |
dc.subject.keywordPlus | Selenium compounds | - |
dc.subject.keywordPlus | Silver compounds | - |
dc.subject.keywordPlus | Targeted drug delivery | - |
dc.subject.keywordPlus | Arabidopsis thaliana | - |
dc.subject.keywordPlus | Drug delivery system | - |
dc.subject.keywordPlus | Metallothioneins | - |
dc.subject.keywordPlus | Novel strategies | - |
dc.subject.keywordPlus | Phytochelatin synthase | - |
dc.subject.keywordPlus | Pseudomonas putida | - |
dc.subject.keywordPlus | Recombinant Escherichia coli | - |
dc.subject.keywordPlus | Reducing reagents | - |
dc.subject.keywordPlus | Metal nanoparticles | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.