Effect of Atorvastatin (10 mg) and Ezetimibe (10 mg) Combination Compared to Atorvastatin (40 mg) Alone on Coronary Atherosclerosis
DC Field | Value | Language |
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dc.contributor.author | Oh, Pyung Chun | - |
dc.contributor.author | Jang, Albert Youngwoo | - |
dc.contributor.author | Ha, Kyungeun | - |
dc.contributor.author | Kim, Minsu | - |
dc.contributor.author | Moon, Jeonggeun | - |
dc.contributor.author | Suh, Soon Yong | - |
dc.contributor.author | Lee, Kyounghoon | - |
dc.contributor.author | Han, Seung Hwan | - |
dc.contributor.author | Kang, Woong Chol | - |
dc.date.accessioned | 2021-09-02T02:40:25Z | - |
dc.date.available | 2021-09-02T02:40:25Z | - |
dc.date.created | 2021-08-09 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 0002-9149 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82011 | - |
dc.description.abstract | It remains inconclusive whether the additional low-density lipoprotein cholesterol (LDL-C) lowering effects of ezetimibe added to statin on coronary atherosclerosis and clinical outcomes are similar to those of statin monotherapy in the setting of comparable LDL-C reduction. We aimed to determine whether there were distinguishable differences in their effects on coronary atherosclerosis with intermediate stenosis between the combination of moderate-intensity statin plus ezetimibe and high-intensity statin monotherapy. Forty-one patients with stable angina undergoing percutaneous coronary intervention were randomized to receive either atorvastatin 10 mg plus ezetimibe 10 mg (ATO10/EZE10) or atorvastatin 40 mg alone (ATO40). The intermediate lesions were evaluated using a near-infrared spectroscopy-intravascular ultrasonography at baseline and after 12 months in 37 patients. The primary endpoint was percent atheroma volume (PAV). Mean LDL-C levels were significantly reduced by 40% and 38% from baseline in the ATO10/EZE10 group (n = 18, from 107 mg/dL to 61 mg/dL) and ATO40 group (n = 19, from 101 mg/dL to 58 mg/dL), respectively, without between-group difference. The absolute change of PAV was −2.9% in the ATO10/EZE10 group and −3.2% in the ATO40 group. The mean difference (95% confidence interval) for the absolute change in PAV between the 2 groups was 0.5% (−2.4% to 2.8%), which did not exceed the pre-defined non-inferiority margin of 5%. There was no significant reduction in lipid core burden index in both groups. In conclusion, the combination of atorvastatin 10 mg and ezetimibe 10 mg showed comparable LDL-C lowering and regression of coronary atherosclerosis in the intermediate lesions, compared with atorvastatin 40 mg alone. © 2021 Elsevier Inc. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | - |
dc.relation.isPartOf | American Journal of Cardiology | - |
dc.title | Effect of Atorvastatin (10 mg) and Ezetimibe (10 mg) Combination Compared to Atorvastatin (40 mg) Alone on Coronary Atherosclerosis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000688261500004 | - |
dc.identifier.doi | 10.1016/j.amjcard.2021.05.039 | - |
dc.identifier.bibliographicCitation | American Journal of Cardiology, v.154, pp.22 - 28 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85111602938 | - |
dc.citation.endPage | 28 | - |
dc.citation.startPage | 22 | - |
dc.citation.title | American Journal of Cardiology | - |
dc.citation.volume | 154 | - |
dc.contributor.affiliatedAuthor | Oh, Pyung Chun | - |
dc.contributor.affiliatedAuthor | Jang, Albert Youngwoo | - |
dc.contributor.affiliatedAuthor | Ha, Kyungeun | - |
dc.contributor.affiliatedAuthor | Kim, Minsu | - |
dc.contributor.affiliatedAuthor | Moon, Jeonggeun | - |
dc.contributor.affiliatedAuthor | Suh, Soon Yong | - |
dc.contributor.affiliatedAuthor | Lee, Kyounghoon | - |
dc.contributor.affiliatedAuthor | Han, Seung Hwan | - |
dc.contributor.affiliatedAuthor | Kang, Woong Chol | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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