Long-Term Treatment of Cuban Policosanol Attenuates Abnormal Oxidative Stress and Inflammatory Response via Amyloid Plaques Reduction in 5xFAD Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jin-Ho | - |
dc.contributor.author | Lim, Dong-Kyun | - |
dc.contributor.author | Suh, Yoo-Hun | - |
dc.contributor.author | Chang, Keun-A | - |
dc.date.accessioned | 2021-09-03T02:41:01Z | - |
dc.date.available | 2021-09-03T02:41:01Z | - |
dc.date.created | 2021-09-03 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82026 | - |
dc.description.abstract | Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in cognitive decline or dementia, the number of patients with AD is continuously increasing. Although a lot of great progress has been made in research and development of AD therapeutics, there is no fundamental cure for this disease yet. This study demonstrated the memory-improving effects of Cuban policosanol (PCO) in 5xFAD mice, which is an animal model of AD. Following 4-months of treatment with PCO in 5xFAD mice, we found that the number of amyloid plaques decreased in the brain compared to the vehicle-treated 5xFAD mice. Long-term PCO treatment in 5xFAD mice resulted in the reduction of gliosis and abnormal inflammatory cytokines level (interleukin [IL]-1 beta, IL-6, and tumor necrosis factor [TNF]-alpha) in the cortex and hippocampus. Levels of lipid peroxide (4-hydroxynonenal [4-HNE]) and superoxide dismutase (SOD1 and SOD2) levels were also recoverd in the brains of PCO-treated 5xFAD mice. Notably, PCO administration reduced memory deficits in the passive avoidance test, as well as synaptic loss (PSD-95, synaptophysin) in 5xFAD mice. Collectively, we identified the potential effects of PCO as a useful supplement to delay or prevent AD progression by inhibiting the formation of A beta plaques in the brain. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | ANTIOXIDANTS | - |
dc.title | Long-Term Treatment of Cuban Policosanol Attenuates Abnormal Oxidative Stress and Inflammatory Response via Amyloid Plaques Reduction in 5xFAD Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000688719600001 | - |
dc.identifier.doi | 10.3390/antiox10081321 | - |
dc.identifier.bibliographicCitation | ANTIOXIDANTS, v.10, no.8 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85113808422 | - |
dc.citation.title | ANTIOXIDANTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Ho | - |
dc.contributor.affiliatedAuthor | Lim, Dong-Kyun | - |
dc.contributor.affiliatedAuthor | Suh, Yoo-Hun | - |
dc.contributor.affiliatedAuthor | Chang, Keun-A | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | policosanol | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | 5xFAD mice | - |
dc.subject.keywordAuthor | antioxidant effects | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | memory improvement | - |
dc.subject.keywordPlus | HIGH-DENSITY-LIPOPROTEIN | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE BRAIN | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | BETA-PEPTIDE | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | PROTEIN OXIDATION | - |
dc.subject.keywordPlus | ANIMAL-MODEL | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.