Anti-diabetic potential of Masclura tricuspidata leaves: Prenylated isoflavonoids with α-glucosidase inhibitory and anti-glycation activity
DC Field | Value | Language |
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dc.contributor.author | Jo, Yang Hee | - |
dc.contributor.author | Lee, Solip | - |
dc.contributor.author | Yeon, Sang Won | - |
dc.contributor.author | Turk, Ayman | - |
dc.contributor.author | Lee, Jae Hyuk | - |
dc.contributor.author | Hong, Seong-Min | - |
dc.contributor.author | Han, Yoo Kyong | - |
dc.contributor.author | Lee, Ki Yong | - |
dc.contributor.author | Hwang, Bang Yeon | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Lee, Mi Kyeong | - |
dc.date.accessioned | 2021-09-07T05:40:22Z | - |
dc.date.available | 2021-09-07T05:40:22Z | - |
dc.date.created | 2021-07-10 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 0045-2068 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82082 | - |
dc.description.abstract | Investigation of chemical constituents of Masclura tricuspidata leaves resulted in the isolation of 47 isoflavonoids possessing prenyl groups with different numbers and structures. Among them, sixteen compounds named cudracusisoflavones A-P (1–16) were first isolated from nature. The isoflavonoids isolated from M. tricuspidata leaves showed anti-diabetic effects as measured by inhibition on α-glucosidase activity and advanced glycation end-products (AGEs) formations. Especially, cudracusisoflavone L (12), a new compound, together with gancaonin M (27), erysenegalensein E (41) and millewanin G (44) showed strong α-glucosidase inhibition with IC50 values <10.0 μM. In addition, cudracusisoflavones A (1), D (4), M (13) and N (14), together with known prenylated isoflavonoids efficiently inhibited methylglyoxal (MGO)- or glyoxal (GO)-induced AGE formations. Structure activity relationship together with molecular docking analysis suggested the importance of hydroxy group and linear type of prenyl moiety for α-glucosidase inhibition. Conclusively, diverse prenylated isoflavonoids in M. tricuspidata leaves might ameliorate glycotoxicity-induced metabolic diseases. © 2021 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | Bioorganic Chemistry | - |
dc.title | Anti-diabetic potential of Masclura tricuspidata leaves: Prenylated isoflavonoids with α-glucosidase inhibitory and anti-glycation activity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000691056400008 | - |
dc.identifier.doi | 10.1016/j.bioorg.2021.105098 | - |
dc.identifier.bibliographicCitation | Bioorganic Chemistry, v.114 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85109048372 | - |
dc.citation.title | Bioorganic Chemistry | - |
dc.citation.volume | 114 | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hyuk | - |
dc.contributor.affiliatedAuthor | Hong, Seong-Min | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Cudracusisoflavones A-P | - |
dc.subject.keywordAuthor | Glycation | - |
dc.subject.keywordAuthor | Masclura tricuspidata | - |
dc.subject.keywordAuthor | Molecular docking analysis | - |
dc.subject.keywordAuthor | Prenylated isoflavonoids | - |
dc.subject.keywordAuthor | α-glucosidase | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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