GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma
- Authors
- Nanda, Sitansu S.; Hossain, Md Imran; Ju, Heongkyu; Yi, Dong Kee
- Issue Date
- Feb-2021
- Publisher
- BENTHAM SCIENCE PUBL LTD
- Keywords
- GSK-3 inhibitor; Colon Carcinoma; Colorectal Cancer; OMM; Cancer Cell Apoptosis; DMSO
- Citation
- CURRENT DRUG TARGETS, v.22, no.13, pp.1485 - 1495
- Journal Title
- CURRENT DRUG TARGETS
- Volume
- 22
- Number
- 13
- Start Page
- 1485
- End Page
- 1495
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82187
- DOI
- 10.2174/1389450122666210204203950
- ISSN
- 1389-4501
- Abstract
- Background: Glycogen syntheis kinase (GSK-3) inhibitors are novel therapeutic agents for treating various types of cancer, such as breast, lung, and gastric cancer. No pathological changes have been found by the morphological examination of GSK-3. Objectives: This review describes recent procedures using GSK-3 inhibitors, primarily in treating colon carcinoma. Furthermore, it also explains the mechanism of action of different GSK-3 inhibitors in treating various types of cancers and proposes some additional mechanisms may be useful for further research on GSK-3 inhibitors for cancers, including colon carcinoma. Results: The majority of the cancerous and pre-cancerous lesions are stimulated by the transformation of membrane-bound arachidonic acid (AA) to eicosanoids, a transformation that promotes for the viability, proliferation, and spread of cancer. GSK-3 inhibitors can reinstate hostility to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) responsiveness in gastric adenocarcinoma cells. GSK-3, the final enzyme in glycogen synthesis, is a serine/threonine kinase that phosphorylates varied sequences that are more than a hundred in number, within proteins in an array of heterogeneous pathways. It is an essential module of an exceptionally large number of cellular processes, playing a fundamental role in many metabolic processes and diseases. Many patients diagnosed with colon cancer achieve long-term remission with outstanding survival through the GSK-3 inhibitors. Conclusion: Prior to the extensive application of these proposed mechanisms of GSK-3 inhibitor, further evaluation and clinical studies are needed. Only after the completion of appropriate clinical studies and morphological examinations, would extensive application be apprpriate.
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