우고닌(Wogonin)이 poly I:C로 유발된 TM4세포 내하이드로겐퍼록사이드 생성에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박완수 | - |
dc.date.accessioned | 2021-10-01T02:40:29Z | - |
dc.date.available | 2021-10-01T02:40:29Z | - |
dc.date.created | 2021-10-01 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1229-1765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82263 | - |
dc.description.abstract | Objectives : The aim of this study is to investigate the effect of wogonin on the production of hydrogen peroxide in polyinosinic:polycytidylic acid (poly I:C)-stimulated TM4 mouse sertoli cells. Methods : TM4 were treated with poly I:C (50 ug/mL) and wogonin at concentrations of 5, 10, 25, and 50 µM for 30 min, 2 hr, 12 hr, 18 hr, and 24 hr. The production of intracellular hydrogen peroxide was measured by dihydrorhodamine 123 assay. Results : For 30 min, 2 hr, 12 hr, 18 hr, and 24 hr treatment, wogonin significantly inhibited intracellular hydrogen peroxide productions of TM4 at the concentration of 5, 10, 25, and 50 µM (p <0.05). In details, production of hydrogen peroxide in poly I:C-stimulated TM4 treated for 30 min with wogonin at concentrations of 5, 10, 25, and 50 µM was 95.67%, 92.69%, 92.05%, and 91.97% of the control group treated with poly I:C only, respectively; the production of hydrogen peroxide for 2 hr was 94.44%, 94.41%, 93%, and 92.98%, respectively; production of hydrogen peroxide for 12 hr was 96.78%, 95.32%, 94.33%, and 93.17%, respectively; production of hydrogen peroxide for 18 hr was 94.7%, 93.4%, 93.38%, and 93.35%, respectively; and production of hydrogen peroxide for 24 hr was 95.75%, 94.77%, 94.58%, and 92.8%, respectively. Conclusions : Wogonin might have anti-viral property related with its inhibition of intracellular hydrogen peroxide production in poly I:C-stimulated TM4 cells. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한본초학회 | - |
dc.relation.isPartOf | 대한본초학회지 | - |
dc.title | 우고닌(Wogonin)이 poly I:C로 유발된 TM4세포 내하이드로겐퍼록사이드 생성에 미치는 영향 | - |
dc.title.alternative | Effect of Wogonin on Intracellular Hydrogen Peroxide Productionof TM4 Mouse Sertoli cells stressed with polyinosinic:polycytidylic acid | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한본초학회지, v.36, no.5, pp.117 - 123 | - |
dc.identifier.kciid | ART002759154 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 123 | - |
dc.citation.startPage | 117 | - |
dc.citation.title | 대한본초학회지 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | 박완수 | - |
dc.subject.keywordAuthor | Sertoli Cell | - |
dc.subject.keywordAuthor | TM4 | - |
dc.subject.keywordAuthor | poly I:C | - |
dc.subject.keywordAuthor | Wogonin | - |
dc.subject.keywordAuthor | Hydrogen Peroxide | - |
dc.subject.keywordAuthor | Reactive Oxygen Species | - |
dc.description.journalRegisteredClass | kci | - |
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