Comparison of the Clinical Features and Outcomes of Gallbladder Neuroendocrine Carcinoma with Those of Adenocarcinoma: A Propensity Score-Matched Analysis
DC Field | Value | Language |
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dc.contributor.author | Do, Min-Young | - |
dc.contributor.author | Jang, Sung-Ill | - |
dc.contributor.author | Kang, Hua-Pyong | - |
dc.contributor.author | Kim, Eui-Joo | - |
dc.contributor.author | Lee, Kyong-Joo | - |
dc.contributor.author | Park, Go-Eun | - |
dc.contributor.author | Lee, Su-Jee | - |
dc.contributor.author | Lee, Dong-Ki | - |
dc.contributor.author | Woo, Sang-Myung | - |
dc.contributor.author | Cho, Jae-Hee | - |
dc.date.accessioned | 2021-10-01T03:40:35Z | - |
dc.date.available | 2021-10-01T03:40:35Z | - |
dc.date.created | 2021-09-27 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82271 | - |
dc.description.abstract | Neuroendocrine neoplasms (NENs) of the gallbladder (GB) are extremely rare. We aimed to compare the clinical features, disease progression, management, and prognosis of patients with GB-NENs with those of patients with GB-adenocarcinomas (ADCs). A total of 21 patients with GB-NENs and 206 patients with GB-ADCs, treated at three tertiary medical centers between January 2010 and December 2020, were enrolled. Of the 21 patients with GB-NENs, 20 were diagnosed with poorly differentiated small-cell neuroendocrine carcinomas (NECs), and 1 patient had large-cell NEC. All patients presented with advanced stages of cancer with extensive local extension and/or distant metastasis and non-specific symptoms. Tumor-node-metastasis stage IIIB and IV (A/B) tumors were found in 6 and 15 (1/14) patients, respectively. Nine patients with GB-NEC who underwent surgical resection had a significantly better progression-free survival (PFS) than those who did not undergo surgery. After a propensity score matching with a 1:1 ratio using the American Joint Committee on Cancer stage, age, sex, and operation status, 19 pairs of patients were included. Compared with stage-matched patients with GB-ADC, patients with GB-NEC had similar overall survival and PFS. However, as GB-NEC is rarely diagnosed early, further studies investigating methods for the early diagnosis and improvement in the survival of patients with GB-NEC are needed. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | Cancers | - |
dc.title | Comparison of the Clinical Features and Outcomes of Gallbladder Neuroendocrine Carcinoma with Those of Adenocarcinoma: A Propensity Score-Matched Analysis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000699327700001 | - |
dc.identifier.doi | 10.3390/cancers13184713 | - |
dc.identifier.bibliographicCitation | Cancers, v.13, no.18 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85115136725 | - |
dc.citation.title | Cancers | - |
dc.citation.volume | 13 | - |
dc.citation.number | 18 | - |
dc.contributor.affiliatedAuthor | Kang, Hua-Pyong | - |
dc.contributor.affiliatedAuthor | Kim, Eui-Joo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Adenocarcinoma | - |
dc.subject.keywordAuthor | Gallbladder | - |
dc.subject.keywordAuthor | Neuroendocrine carcinoma | - |
dc.subject.keywordAuthor | Neuroendocrine neoplasm | - |
dc.subject.keywordAuthor | Propensity score matching | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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