Pediococcus Pentosaceus from the Sweet Potato Fermented Ger-Minated Brown Rice Can Inhibit Type I Hypersensitivity in RBL-2H3 Cell and BALB/c Mice Models
DC Field | Value | Language |
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dc.contributor.author | Dhong, Kyu-Ree | - |
dc.contributor.author | Park, Hye-Jin | - |
dc.date.accessioned | 2021-10-04T01:40:32Z | - |
dc.date.available | 2021-10-04T01:40:32Z | - |
dc.date.created | 2021-09-09 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 2076-2607 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82299 | - |
dc.description.abstract | In this study, the effect of GBR fermented with the Pediococcus pentosaceus SP024 strain on IgE/Ag mediated passive cutaneous anaphylaxis (PCA) was investigated. Protocatechuic acid and trans-ferulic acid levels in GBR-SP024 increased more than those in unfermented GBR, respec-tively. The inhibitory activity of GBR-SP024 on β-hexosaminidase release and the level of proin-flamma-tory cytokine mRNA expression (tumor necrosis factor-α (TNF-α) and interleukin 4 (IL-4)) was observed in IgE/Ag-stimulated RBL-2H3 cells. Western blot analysis showed that GBR-SP024 significantly inhibited the phosphorylation of the linker for activation of T cell (LAT) and nuclear factor-κB (NF-κB) in IgE/Ag-stimulated RBL-2H3 cells. Further, we investigated the anti-allergic effect of GBR-SP024 using PCA murine model. The number of infiltrated immune cells and degranulated mast cells in GBR-SP024 treated dermis was lower than that in the GBR-treated mice. In addition, mRNA expression of 5-lipoxygenase (5-LOX) in the dermis of ear tissue declined in the GBR-SP024– treated group, compared to that in the GBR group. GBR-SP024 was also more effective than GBR at reducing the levels of IL-33 protein expression in IgE/Ag-stimulated BALB/c mice. Our study sug-gests the potential usage of GBR-SP024 as a dietary supplement or an adjuvant for treating IgE-dependent-allergic diseases. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | Microorganisms | - |
dc.title | Pediococcus Pentosaceus from the Sweet Potato Fermented Ger-Minated Brown Rice Can Inhibit Type I Hypersensitivity in RBL-2H3 Cell and BALB/c Mice Models | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000701065800001 | - |
dc.identifier.doi | 10.3390/microorganisms9091855 | - |
dc.identifier.bibliographicCitation | Microorganisms, v.9, no.9 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85114095925 | - |
dc.citation.title | Microorganisms | - |
dc.citation.volume | 9 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Dhong, Kyu-Ree | - |
dc.contributor.affiliatedAuthor | Park, Hye-Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Anti-allergy | - |
dc.subject.keywordAuthor | Basophil | - |
dc.subject.keywordAuthor | Germinated brown rice fermented with lactic acid bacteria | - |
dc.subject.keywordAuthor | Mast cell | - |
dc.subject.keywordAuthor | Type I hypersensitive disease | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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