A Combination Extract of Gardeniae Fructus and Perillae Folium Exerts Anti-Inflammatory Effects on LPS-Activated RAW 264.7 Mouse Macrophages via an ER Stress-Induced CHOP Pathway
DC Field | Value | Language |
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dc.contributor.author | Park, Wansu | - |
dc.date.accessioned | 2021-10-08T03:40:08Z | - |
dc.date.available | 2021-10-08T03:40:08Z | - |
dc.date.created | 2021-10-08 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 2227-9717 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82333 | - |
dc.description.abstract | The aim of this study is to investigate the effects of a combination extract of Gardeniae Fructus and Perillae Folium (GP) on inflammatory reactions in lipopolysaccharide (LPS)-activated mouse macrophages RAW 264.7 cells. Multiplex cytokine assay, Fluo-4 calcium assay, Flow cytometry assay for phospho-P38 MAPK, and quantitative PCR were carried out. GP significantly reduced LPS-induced productions of macrophage inflammatory protein (MIP)-1 alpha and monokine induced by gamma interferon (MIG) and release of intracellular calcium in LPS-activated RAW 264.7 cells. GP also significantly inhibited P38 MAPK phosphorylation and mRNA levels of Chop, Camk2a, Stat1, Stat3, Jak2, Fas, Nos2, and Ptgs2 in LPS-activated RAW 264.7 cells. Taken together, this study represents that GP exerts anti-inflammatory effects on LPS-activated RAW 264.7 cells via ER stress-induced CHOP pathway. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | PROCESSES | - |
dc.title | A Combination Extract of Gardeniae Fructus and Perillae Folium Exerts Anti-Inflammatory Effects on LPS-Activated RAW 264.7 Mouse Macrophages via an ER Stress-Induced CHOP Pathway | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000701888200001 | - |
dc.identifier.doi | 10.3390/pr9091632 | - |
dc.identifier.bibliographicCitation | PROCESSES, v.9, no.9 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85116001709 | - |
dc.citation.title | PROCESSES | - |
dc.citation.volume | 9 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Park, Wansu | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Gardeniae Fructus | - |
dc.subject.keywordAuthor | Perillae Folium | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | CHOP | - |
dc.subject.keywordAuthor | calcium | - |
dc.subject.keywordAuthor | P38 MAPK | - |
dc.subject.keywordPlus | WATER EXTRACT | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | FRUTESCENS | - |
dc.subject.keywordPlus | LEAVES | - |
dc.subject.keywordPlus | CHROMATOGRAPHY | - |
dc.subject.keywordPlus | ENDOTOXIN | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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