Intra-articular injection of bone marrow-derived mesenchymal stem cells leading to better clinical outcomes without difference in mri outcomes from baseline in patients with knee osteoarthritis
- Authors
- Shin, Y.-S.; Yoon, J.-R.; Kim, H.-S.; Lee, S.-H.
- Issue Date
- Sep-2018
- Publisher
- Korean Knee Society
- Keywords
- Bone marrow; Knee; Mesenchymal stem cells; Meta-analysis; Osteoarthritis
- Citation
- Knee Surgery and Related Research, v.30, no.3, pp.206 - 214
- Journal Title
- Knee Surgery and Related Research
- Volume
- 30
- Number
- 3
- Start Page
- 206
- End Page
- 214
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82467
- DOI
- 10.5792/ksrr.17.201
- ISSN
- 2234-0726
- Abstract
- Purpose: Bone marrow (BM) is frequently used as a source of mesenchymal stem cells (MSCs) because they have a high potential for differentiation. However, it is unclear whether BM-derived MSCs lead to better clinical and magnetic resonance imaging (MRI) outcomes postoperatively. Materials and Methods: This meta-analysis compared the clinical and MRI outcomes in patients with knee osteoarthritis (OA) treated with BM-derived MSCs. Eight studies comparing the clinical and MRI outcomes assessed with various measurement tools in patients with knee OA treated with BM-derived MSCs were included. Results: The range of motion (95% confidence interval [CI], –13.05 to 4.24; p=0.32) and MRI outcomes (95% CI, –0.16 to 1.40; p=0.12) did not differ significantly between the baseline and final follow-up. In contrast, pain (95% CI, 0.89 to 1.87; p<0.001) and functional outcomes (95% CI, 0.70 to 2.07; p<0.001) were significantly improved at the final follow-up when compared to the baseline. Conclusions: This meta-analysis found no significant difference in the tested range of motion and MRI outcomes between the baseline and the final follow-up in patients treated with BM-derived MSCs, whereas significant functional improvement and pain relief were noted when compared with the baseline. Thus, BM-derived MSCs appear to be a viable alternative for patients with knee OA, although long-term and high-quality randomized controlled trials are needed to confirm the clinical benefits. © 2018 KOREAN KNEE SOCIETY.
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