Long-term exposure to ambient air pollutants and age-related macular degeneration in middle-aged and older adults
- Authors
- Ju, Min Jae; Kim, Junghoon; Park, Sung Kyun; Kim, Dong Hyun; Choi, Yoon-Hyeong
- Issue Date
- Mar-2022
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- AMD; Air pollution; Long-term exposure; PM10; NO2; CO
- Citation
- ENVIRONMENTAL RESEARCH, v.204
- Journal Title
- ENVIRONMENTAL RESEARCH
- Volume
- 204
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82491
- DOI
- 10.1016/j.envres.2021.111953
- ISSN
- 0013-9351
- Abstract
- In developed countries, age-related macular degeneration (AMD) is a leading cause of irreversible blindness in adults. The key pathways of AMD are suggested to be excessive oxidative stress and inflammation in the central retina. Because air pollution has been found capable of inducing oxidative stress and inflammation, it may play a role in development of AMD. This study investigated the association between ambient air pollution and AMD in 15,115 middle-aged and older adults (>= 40 years) from Korean National Health and Nutrition Examination Survey 2008-2012. After controlling for important confounders, ambient NO2 and CO in current-to-5 prior years and PM10 in 2-to-5 prior years were significantly associated with higher prevalence of early AMD, while O3 in current-to-5 prior years was significantly associated with lower prevalence of early AMD. When modeled air pollution within administrative division units, its ORs with an IQR increase in NO2, CO, and O3 at current year were 1.24 (95% CI: 1.05-1.46), 1.22 (95% CI: 1.09-1.38), and 0.80 (95% CI: 0.70-0.92), respectively. Overall, results from air pollution at local/town units were consistent with those at administrative division units. Longterm exposures to ambient air pollution may play a role in the risk of AMD in middle-aged and older adults.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의예과 > 1. Journal Articles
- 의과대학 > 의학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.