Antibacterial toxicity of mesoporous silica nanoparticles with functional decoration of specific organic moieties
DC Field | Value | Language |
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dc.contributor.author | Son, Min Ji | - |
dc.contributor.author | Lee, Sang-Wha | - |
dc.date.accessioned | 2021-10-25T00:40:19Z | - |
dc.date.available | 2021-10-25T00:40:19Z | - |
dc.date.created | 2021-10-04 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 0927-7757 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82497 | - |
dc.description.abstract | Mesoporous silica nanoparticles (MSNs) are generally considered as biocompatible nanocarriers for biomedical applications; however, no study has provided conclusive evidence regarding the antimicrobial toxicity of MSNs. Here, we systematically evaluated the toxicity of MSNs against Escherichia coli (E. coli) by investigating not only the removal rate of cetyltrimethyl ammonium bromide (CTAB) from the MSNs, but also functional decorations of specific organic moieties such as polydopamine (PDA) and graphene oxide (GO). The mortality of E coli was strongly dependent on the residual CTAB that was not completely removed from the MSNs by acid etching process. On the other hand, for the removal of CTAB from the MSNs the reduced etching time and increased H2O content in the etchant increased the survival of E. coli, probably because of the reduction of bioactive H+ ions that inhibit bacterial growth. Notably, PDA-coated and GO-wrapped MSNs demonstrated the higher toxicity than the pristine MSNs, because of the strong interplay of antibacterial activity of functional decoration (PDA and GO). This study provides a useful guideline for the design of biocompatible MSNs for biomedical applications. © 2021 Elsevier B.V. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | - |
dc.title | Antibacterial toxicity of mesoporous silica nanoparticles with functional decoration of specific organic moieties | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000707049700002 | - |
dc.identifier.doi | 10.1016/j.colsurfa.2021.127612 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v.630 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85115889105 | - |
dc.citation.title | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | - |
dc.citation.volume | 630 | - |
dc.contributor.affiliatedAuthor | Son, Min Ji | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Wha | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Antibacterial toxicity | - |
dc.subject.keywordAuthor | Graphene oxide | - |
dc.subject.keywordAuthor | Mesoporous silica nanoparticles | - |
dc.subject.keywordAuthor | Polydopamine | - |
dc.subject.keywordPlus | Biocompatibility | - |
dc.subject.keywordPlus | Escherichia coli | - |
dc.subject.keywordPlus | Etching | - |
dc.subject.keywordPlus | Graphene | - |
dc.subject.keywordPlus | Medical applications | - |
dc.subject.keywordPlus | Mesoporous materials | - |
dc.subject.keywordPlus | Silica nanoparticles | - |
dc.subject.keywordPlus | Antibacterial toxicity | - |
dc.subject.keywordPlus | Antibacterials | - |
dc.subject.keywordPlus | Biomedical applications | - |
dc.subject.keywordPlus | Cetyltrimethylammonium bromide | - |
dc.subject.keywordPlus | E. coli | - |
dc.subject.keywordPlus | Mesoporous silica nanoparticles | - |
dc.subject.keywordPlus | Nanocarriers | - |
dc.subject.keywordPlus | Organic moiety | - |
dc.subject.keywordPlus | Polydopamine | - |
dc.subject.keywordPlus | Removal rate | - |
dc.subject.keywordPlus | Toxicity | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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