Fabrication of hydrogel-encapsulated silica core bound with chitosan chains for efficient drug delivery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Saet Byeol | - |
dc.contributor.author | Lee, Sang Wha | - |
dc.date.available | 2020-02-28T01:45:03Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-06 | - |
dc.identifier.issn | 0021-4922 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8249 | - |
dc.description.abstract | In this study, hydrogel-encapsulated silica nanoparticles were facilely prepared through the following three consecutive steps: i) silica nanoparticles (SNPs) were synthesized via a sol-gel reaction of tetraethyl orthosilicate (TEOS) with ammonium hydroxide, ii) the resulting SNPs were functionalized with 3-(trimethoxysilyl)-propylmethacrylate (TPM) ligand with an olefin group, and iii) the TPM-functionalized SNPs were encapsulated with poly(N-isopropylacrylamide-co-acrylic acid), NIPAM-co-AAc hydrogels by using a radical polymerization reaction of the comonomers at the following ratio: NIPAM : AAc = 91 : 9 wt %. The lower critical solution temperature (LCST) of the encapsulated hydrogels with a moiety of carboxylic groups was slightly above physiological temperature and they demonstrated a thermo-sensitive variation of particle size. The hydrogel-encapsulated SNPs (SNPs@Hyd) were finally bound with chitosan chains, which are bio-friendly and non-toxic polymers. When compared to SNPs@Hyd, chitosan-coated SNPs@Hyd (SNPs@Hyd@Chi) exhibited prolonged drug (ibuprofen) release and stable structural integrity during the release test. (C) 2016 The Japan Society of Applied Physics | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IOP PUBLISHING LTD | - |
dc.relation.isPartOf | JAPANESE JOURNAL OF APPLIED PHYSICS | - |
dc.subject | POLY(N-ISOPROPYLACRYLAMIDE-CO-ACRYLIC ACID) HYDROGELS | - |
dc.subject | GOLD NANOPARTICLES | - |
dc.subject | RELEASE | - |
dc.subject | CHEMISTRY | - |
dc.subject | GROWTH | - |
dc.subject | DOTS | - |
dc.title | Fabrication of hydrogel-encapsulated silica core bound with chitosan chains for efficient drug delivery | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000377484100035 | - |
dc.identifier.doi | 10.7567/JJAP.55.06GH03 | - |
dc.identifier.bibliographicCitation | JAPANESE JOURNAL OF APPLIED PHYSICS, v.55, no.6 | - |
dc.identifier.scopusid | 2-s2.0-84974602640 | - |
dc.citation.title | JAPANESE JOURNAL OF APPLIED PHYSICS | - |
dc.citation.volume | 55 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Bae, Saet Byeol | - |
dc.contributor.affiliatedAuthor | Lee, Sang Wha | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.subject.keywordPlus | POLY(N-ISOPROPYLACRYLAMIDE-CO-ACRYLIC ACID) HYDROGELS | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | DOTS | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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