Effect of Astaxanthin on Anti-Inflammatory and Anti-Oxidative Effects of Astaxanthin Treatment for Atopic Dermatitis-induced Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박진우 | - |
dc.contributor.author | 송호섭 | - |
dc.date.accessioned | 2021-11-27T02:40:22Z | - |
dc.date.available | 2021-11-27T02:40:22Z | - |
dc.date.created | 2021-11-27 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 2586-288X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82756 | - |
dc.description.abstract | Background: This study sought to determine whether the antioxidant effects of astaxanthin (AST) could have an anti-inflammatory effect to reduce inflammation caused by atopic dermatitis (AD).Methods: Using a mouse model of AD induced by phtalic acid (PA), the levels of inflammation, inflammatory agents, and evidence of antioxidant activity were examined in PA treated mice (n = 3), PA-AST treated mice (n = 3), and a control group of mice (n = 3). This included measurements of ear thickness, levels of mast cells, IgE, inflammatory cytokine, malondialdehyde (MDA), hydrogen peroxide, HO-1, and GPx-1.Results: AST treatment significantly prevented inflammation as measured by ear thickness (p < 0.05), mast cell count (p < 0.001), and IgE concentration in the blood (p < 0.001). Levels of TNF-α (p < 0.001), IL-1β (p < 0.001), IL-6 (p < 0.001), and MDA (p < 0.05) were also significantly lower. In addition, GSH levels increased significantly (p < 0.001), and the level of hydrogen peroxide significantly reduced (p < 0.01). The expression of HO-1, GPx-1 increased.Conclusion: In this small experimental study, AST acted on inflammatory mechanisms that induced AD, through anti-inflammatory and antioxidant mechanisms, and is a candidate of interest in the clinical treatment of AD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한침구의학회 | - |
dc.relation.isPartOf | Journal of Acupuncture Research | - |
dc.title | Effect of Astaxanthin on Anti-Inflammatory and Anti-Oxidative Effects of Astaxanthin Treatment for Atopic Dermatitis-induced Mice | - |
dc.title.alternative | Effect of Astaxanthin on Anti-Inflammatory and Anti-Oxidative Effects of Astaxanthin Treatment for Atopic Dermatitis-induced Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.doi | 10.13045/jar.2021.00178 | - |
dc.identifier.bibliographicCitation | Journal of Acupuncture Research, v.38, no.4, pp.293 - 299 | - |
dc.identifier.kciid | ART002777370 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 299 | - |
dc.citation.startPage | 293 | - |
dc.citation.title | Journal of Acupuncture Research | - |
dc.citation.volume | 38 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | 박진우 | - |
dc.contributor.affiliatedAuthor | 송호섭 | - |
dc.subject.keywordAuthor | astaxanthin | - |
dc.subject.keywordAuthor | atopic dermatitis | - |
dc.subject.keywordAuthor | anti-inflammation anti-oxidative | - |
dc.description.journalRegisteredClass | kci | - |
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