Schisandrin C Affects Glucose-Stimulated Insulin Secretion in Pancreatic beta-Cells and Glucose Uptake in Skeletal Muscle Cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Kim, Young-Mi | - |
dc.contributor.author | Kim, Hyun Woo | - |
dc.contributor.author | Choi, You-Kyoung | - |
dc.contributor.author | Park, Bang Ju | - |
dc.contributor.author | Joo, Sang Hoon | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.accessioned | 2021-11-28T03:40:51Z | - |
dc.date.available | 2021-11-28T03:40:51Z | - |
dc.date.created | 2021-11-28 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82779 | - |
dc.description.abstract | The aim of our study was to investigate the effect of three lignans (schisandrol A, schisandrol B, and schisandrin C) on insulin secretion in rat INS-1 pancreatic beta-cells and glucose uptake in mouse C2C12 skeletal muscle cells. Schisandrol A and schisandrin C enhanced insulin secretion in response to high glucose levels with no toxic effects on INS-1 cells. The effect of schisandrin C was superior to that of gliclazide (positive control), a drug commonly used to treat type 2 diabetes (T2D). In addition, western blot analysis showed that the expression of associated proteins, including peroxisome proliferator-activated receptor gamma (PPAR gamma), pancreatic and duodenal homeobox 1 (PDX-1), phosphatidylinositol 3-kinase (PI3K), Akt, and insulin receptor substrate-2 (IRS-2), was increased in INS-1 cells after treatment with schisandrin C. In addition, insulin secretion effect of schisandrin C were enhanced by the Bay K 8644 (L-type Ca2+ channel agonist) and glibenclamide (K+ channel blocker), were abolished by the nifedipine (L-type Ca2+ channel blocker) and diazoxide (K+ channel activator). Moreover, schisandrin C enhanced glucose uptake with no toxic effects on C2C12 cells. Western blot analysis showed that the expression of associated proteins, including insulin receptor substrate-1 (IRS-1), AMP-activated protein kinase (AMPK), PI3K, Akt, glucose transporter type 4 (GLUT-4), was increased in C2C12 cells after treatment with schisandrin C. Schisandrin C may improve hyperglycemia by enhancing insulin secretion in pancreatic beta-cells and improving glucose uptake into skeletal muscle cells. Our findings may provide evidence that schisandrin C may be beneficial in devising novel anti-T2D strategies. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MOLECULES | - |
dc.title | Schisandrin C Affects Glucose-Stimulated Insulin Secretion in Pancreatic beta-Cells and Glucose Uptake in Skeletal Muscle Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000718998500001 | - |
dc.identifier.doi | 10.3390/molecules26216509 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.26, no.21 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85120666189 | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 26 | - |
dc.citation.number | 21 | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Choi, You-Kyoung | - |
dc.contributor.affiliatedAuthor | Park, Bang Ju | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | schisandrin C | - |
dc.subject.keywordAuthor | glucose-stimulated insulin secretion | - |
dc.subject.keywordAuthor | glucose uptake | - |
dc.subject.keywordAuthor | PDX-1 | - |
dc.subject.keywordAuthor | GLUT-4 | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CHINENSIS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | LIGNANS | - |
dc.subject.keywordPlus | GLUT4 | - |
dc.subject.keywordPlus | FRUIT | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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