One-pot synthesis of carbon dots with intrinsic folic acid for synergistic imaging-guided photothermal therapy of prostate cancer cells
DC Field | Value | Language |
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dc.contributor.author | Le Minh Tu Phan | - |
dc.contributor.author | Gul, Anam Rana | - |
dc.contributor.author | Thi Ngoc Le | - |
dc.contributor.author | Kim, Min Woo | - |
dc.contributor.author | Kailasa, Suresh Kumar | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.contributor.author | Park, Tae Jung | - |
dc.date.accessioned | 2021-12-07T07:40:30Z | - |
dc.date.available | 2021-12-07T07:40:30Z | - |
dc.date.created | 2021-12-07 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 2047-4830 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82868 | - |
dc.description.abstract | Photothermal therapy (PTT) is performed using near-infrared-responsive agents, which is proven to be an effective therapeutic strategy against cancer with several advantages including minimal invasion, high effectiveness, and easy implementation. Herein, we report a facile and novel one-pot synthetic approach for the fabrication of polydopamine-folate carbon dots (PFCDs) as theranostic nanocarriers for the image-guided PTT targeting of prostate cancer (PCa) cells that express a prostate-specific membrane antigen (PSMA) (folate hydrolase 1). The as-fabricated PFCDs exhibited several advantages such as easy preparation, high biocompatibility, low toxicity, good water-solubility, and excellent photothermal effect with robust blue fluorescence emission. The PSMA-directed imaging of PCa using PFCDs showed remarkable fluorescence enhancement in LNCap cells as compared to the case of other cells that did not express PSMA. PFCDs exhibited a photothermal effect in the PCa cells when irradiated with an 808 nm laser, which possibly resulted in the complete elimination of the tumor. Thus, these features make PFCDs a promising candidate for PTT. Moreover, PFCD-based PTT provides an effective biomedical platform for cancer therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | BIOMATERIALS SCIENCE | - |
dc.title | One-pot synthesis of carbon dots with intrinsic folic acid for synergistic imaging-guided photothermal therapy of prostate cancer cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000504250100021 | - |
dc.identifier.doi | 10.1039/c9bm01228a | - |
dc.identifier.bibliographicCitation | BIOMATERIALS SCIENCE, v.7, no.12, pp.5187 - 5196 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85075282568 | - |
dc.citation.endPage | 5196 | - |
dc.citation.startPage | 5187 | - |
dc.citation.title | BIOMATERIALS SCIENCE | - |
dc.citation.volume | 7 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Le Minh Tu Phan | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TARGETED DRUG-DELIVERY | - |
dc.subject.keywordPlus | MEMBRANE ANTIGEN PSMA | - |
dc.subject.keywordPlus | POLYMERIC NANOPARTICLES | - |
dc.subject.keywordPlus | SURFACE MODIFICATION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | POLYDOPAMINE | - |
dc.subject.keywordPlus | FLUORESCENT | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | FOLATE | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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