Extra-basal ganglia iron content and non-motor symptoms in drug-naive, early Parkinson's disease
DC Field | Value | Language |
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dc.contributor.author | Kim, Minkyeong | - |
dc.contributor.author | Yoo, Seulki | - |
dc.contributor.author | Kim, Doyeon | - |
dc.contributor.author | Cho, Jin Whan | - |
dc.contributor.author | Kim, Ji Sun | - |
dc.contributor.author | Ahn, Jong Hyun | - |
dc.contributor.author | Mun, Jun Kyu | - |
dc.contributor.author | Choi, Inyoung | - |
dc.contributor.author | Lee, Seung-Kyun | - |
dc.contributor.author | Youn, Jinyoung | - |
dc.date.accessioned | 2021-12-09T00:40:59Z | - |
dc.date.available | 2021-12-09T00:40:59Z | - |
dc.date.created | 2021-05-03 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1590-1874 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82897 | - |
dc.description.abstract | Background Although iron dyshomeostasis is associated with Parkinson's disease (PD) pathogenesis, the relationship between iron deposition and non-motor involvement in PD is not fully understood. In this study, we investigated basal ganglia and extra-basal ganglia system iron contents and their correlation with non-motor symptoms in drug-naive, early-stage PD patients. Methods We enrolled 14 drug-naive, early-stage PD patients and 12 age/sex-matched normal controls. All participants underwent brain magnetic resonance imaging to obtain the effective transverse relaxation rate (R2*) and quantitative susceptibility mapping (QSM). Deep brain structures, including the nucleus accumbens, caudate nucleus, putamen, globus pallidus, thalamus, hippocampus, and amygdala, were delineated using the FSL-FIRST; the substantia nigra, red nucleus, and dentate nucleus were segmented manually. Inter-group differences in R2* and QSM values, as well as their association with clinical parameters of PD, were investigated. Results Substantia nigra and putamen R2* values were significantly higher in PD patients than in normal controls, despite no significant difference in QSM values. Regarding the non-motor symptom scales, PD sleep scale score negatively correlated with R2* values in the red nucleus and right amygdala, Scales for Outcomes in Parkinson's disease-Autonomic scores were positively correlated with R2* values in the right amygdala and left hippocampus, and cardiovascular sub-score of Non-Motor Symptoms Scale for PD was positively associated with the QSM value in the left hippocampus. Conclusion In this study, iron content in the extra-basal ganglia system was significantly correlated with non-motor symptoms, especially sleep problems and dysautonomia, even in early-stage PD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER-VERLAG ITALIA SRL | - |
dc.relation.isPartOf | NEUROLOGICAL SCIENCES | - |
dc.title | Extra-basal ganglia iron content and non-motor symptoms in drug-naive, early Parkinson's disease | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000640760700001 | - |
dc.identifier.doi | 10.1007/s10072-021-05223-0 | - |
dc.identifier.bibliographicCitation | NEUROLOGICAL SCIENCES, v.42, no.12, pp.5297 - 5304 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85104766080 | - |
dc.citation.endPage | 5304 | - |
dc.citation.startPage | 5297 | - |
dc.citation.title | NEUROLOGICAL SCIENCES | - |
dc.citation.volume | 42 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Kim, Doyeon | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordAuthor | R2* | - |
dc.subject.keywordAuthor | Quantitative susceptibility mapping | - |
dc.subject.keywordAuthor | Iron | - |
dc.subject.keywordAuthor | Parkinson& | - |
dc.subject.keywordAuthor | #8217 | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Non-motor | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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