Current Potential Therapeutic Approaches against SARS-CoV-2: A Review
- Authors
- Yadav, Dharmendra Kumar; Singh, Desh Deepak; Han, Ihn; Kumar, Yogesh; Choi, Eun-Ha
- Issue Date
- Nov-2021
- Publisher
- MDPI
- Keywords
- Combination therapy; Host-based therapy; SARS-CoV-2; SARS-CoV-2 cell entry inhibitors; Virus-based therapy
- Citation
- Biomedicines, v.9, no.11
- Journal Title
- Biomedicines
- Volume
- 9
- Number
- 11
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82900
- DOI
- 10.3390/biomedicines9111620
- ISSN
- 2227-9059
- Abstract
- The ongoing SARS-CoV-2 pandemic is a serious threat to public health worldwide and, to date, no effective treatment is available. Thus, we herein review the pharmaceutical approaches to SARS-CoV-2 infection treatment. Numerous candidate medicines that can prevent SARS-CoV-2 infection and replication have been proposed. These medicines include inhibitors of serine protease TMPRSS2 and angiotensin converting enzyme 2 (ACE2). The S protein of SARS-CoV-2 binds to the receptor in host cells. ACE2 inhibitors block TMPRSS2 and S protein priming, thus preventing SARS-CoV-2 entry to host cells. Moreover, antiviral medicines (including the nucleotide analogue remdesivir, the HIV protease inhibitors lopinavir and ritonavir, and wide-spectrum antiviral antibiotics arbidol and favipiravir) have been shown to reduce the dissemination of SARS-CoV-2 as well as morbidity and mortality associated with COVID-19. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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