Targeting Cancer Stem Cell Markers or Pathways: A Potential Therapeutic Strategy for Oral Cancer Treatment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jin Woo | - |
dc.contributor.author | Lee, Hwa-Yong | - |
dc.date.accessioned | 2021-12-09T00:41:26Z | - |
dc.date.available | 2021-12-09T00:41:26Z | - |
dc.date.created | 2021-11-11 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 2005-3606 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82904 | - |
dc.description.abstract | Cancer stem cells (CSCs) are a small subset of cancer cells with stem cell-like properties, self-renewal potential, and differentiation capacity into multiple cell types. Critical genetic alterations or aberrantly activated signaling pathways associated with drug resistance and recurrence have been observed in multiple types of CSCs. In this context, CSCs are considered to be responsible for tumor initiation, growth, progression, therapeutic resistance, and metastasis. Therefore, to effectively eradicate CSCs, tremendous efforts have been devoted to identify specific target molecules that play a critical role in regulating their distinct functions and to develop novel therapeutics, such as proteins, monoclonal antibodies, selective small molecule inhibitors, and small antisense RNA (asRNA) drugs. Similar to other CSC types, oral CSCs can be characterized by certain pluripotency-associated markers, and oral CSCs can also survive and form 3D tumor spheres in suspension culture conditions. These oral CSC-targeting therapeutics selectively suppress specific surface markers or key signaling components and subsequently inhibit the stem-like properties of oral CSCs. A large number of new therapeutic candidates have been tested, and some products are currently in the pre-clinical or clinical development phase. In the present study, we review new oral CSC-targeted therapeutic strategies and discuss the various specific CSC surface markers and key signaling components involved in the stem-like properties, growth, drug resistance, and tumorigenicity of oral CSCs. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC STEM CELL RESEARCH | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF STEM CELLS | - |
dc.title | Targeting Cancer Stem Cell Markers or Pathways: A Potential Therapeutic Strategy for Oral Cancer Treatment | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000712881400001 | - |
dc.identifier.doi | 10.15283/ijsc21084 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF STEM CELLS, v.14, no.4, pp.386 - 399 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85121471119 | - |
dc.citation.endPage | 399 | - |
dc.citation.startPage | 386 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF STEM CELLS | - |
dc.citation.volume | 14 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Lee, Jin Woo | - |
dc.type.docType | Review; Early Access | - |
dc.subject.keywordAuthor | Cancer stem cells | - |
dc.subject.keywordAuthor | Stem cell-like characteristics | - |
dc.subject.keywordAuthor | Drug resistance | - |
dc.subject.keywordAuthor | Recurrence | - |
dc.subject.keywordPlus | HEDGEHOG SIGNALING PATHWAY | - |
dc.subject.keywordPlus | ALDEHYDE DEHYDROGENASE 1 | - |
dc.subject.keywordPlus | NECK-CANCER | - |
dc.subject.keywordPlus | C-KIT | - |
dc.subject.keywordPlus | SELF-RENEWAL | - |
dc.subject.keywordPlus | INITIATING CELLS | - |
dc.subject.keywordPlus | CARCINOMA CELLS | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL COACTIVATOR | - |
dc.subject.keywordPlus | PROSPECTIVE IDENTIFICATION | - |
dc.subject.keywordPlus | MYELOID-LEUKEMIA | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.