Lactic Acid Bacteria Fermented Cordyceps militaris (GRC-SC11) Suppresses IgE Mediated Mast Cell Activation and Type I Hypersensitive Allergic Murine Model
DC Field | Value | Language |
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dc.contributor.author | Phull, Abdul-Rehman | - |
dc.contributor.author | Dhong, Kyu-Ree | - |
dc.contributor.author | Park, Hye-Jin | - |
dc.date.accessioned | 2021-12-09T00:41:28Z | - |
dc.date.available | 2021-12-09T00:41:28Z | - |
dc.date.created | 2021-11-04 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82905 | - |
dc.description.abstract | Cordyceps militaris (C. militaris) has various biomedical applications in traditional orien-tal medicine for different diseases including inflammatory and immune-dysregulated diseases. It is a reservoir of nutritional components such as cordycepin, polysaccharides, and antioxidants. To improve its bioactivity, we fermented C. militaris with a Pediococcus pentosaceus strain isolated from a salted small octopus (SC11). The current study aimed to evaluate whether P. pentosaceus (SC11) fermentation could enhance the anti-allergic potential of C. militaris cultured on germinated Rhynchosia nulubilis (GRC) against a type I hypersensitive reaction in in vitro and in vivo studies. Total antioxidant capacity and cordycepin content were significantly increased in GRC after SC11 fermentation. GRC-SC11 showed significantly enhanced anti-allergic responses by inhibiting im-munoglobulin E (IgE)/antigen-induced degranulation in RBL-2H3 cells, compared to GRC. The results demonstrated the significant inhibition of phosphorylated spleen tyrosine kinase (Syk)/ p38/GRB2-associated binding protein 2 (Gab2)/c-jun in IgE/Ag-triggered RBL-2H3 cells. Fur-thermore, suppressed mRNA levels of interleukin-4 (IL-4) and tumor necrosis factor-α (TNF-α) in IgE/Ag-activated RBL-2H3 cells were observed. GRC-SC11 significantly ameliorated IgE-induced allergic reactions by suppressing the ear swelling, vascular permeability, and inflammatory cell infiltration in passive cutaneous anaphylaxis (PCA) BALB/c mice. In conclusion, GRC fermented with P.pentosaceus exerted enhanced anti-allergic effects, and increased the cordycepin content and antioxidants potential compared to GRC. It can be used as bio-functional food in the prevention and management of type I allergic diseases. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | Nutrients | - |
dc.title | Lactic Acid Bacteria Fermented Cordyceps militaris (GRC-SC11) Suppresses IgE Mediated Mast Cell Activation and Type I Hypersensitive Allergic Murine Model | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000724486500001 | - |
dc.identifier.doi | 10.3390/nu13113849 | - |
dc.identifier.bibliographicCitation | Nutrients, v.13, no.11 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85117954703 | - |
dc.citation.title | Nutrients | - |
dc.citation.volume | 13 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Phull, Abdul-Rehman | - |
dc.contributor.affiliatedAuthor | Dhong, Kyu-Ree | - |
dc.contributor.affiliatedAuthor | Park, Hye-Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Anti-allergy | - |
dc.subject.keywordAuthor | Cordyceps militaris | - |
dc.subject.keywordAuthor | Fermentation | - |
dc.subject.keywordPlus | ANTIALLERGIC ACTIVITY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ANAPHYLAXIS | - |
dc.subject.keywordPlus | MICROBIOTA | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | VITRO | - |
dc.subject.keywordPlus | MICE | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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