Metabolic Subtyping of Adrenal Tumors: Prospective Multi-Center Cohort Study in Korea
DC Field | Value | Language |
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dc.contributor.author | 구유정 | - |
dc.contributor.author | 이채린 | - |
dc.contributor.author | 심재윤 | - |
dc.contributor.author | 이시훈 | - |
dc.contributor.author | 김경아 | - |
dc.contributor.author | 김상완 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 김효정 | - |
dc.contributor.author | 임정수 | - |
dc.contributor.author | 정춘희 | - |
dc.contributor.author | 전성완 | - |
dc.contributor.author | 유순집 | - |
dc.contributor.author | 류옥현 | - |
dc.contributor.author | 조호찬 | - |
dc.contributor.author | 홍아람 | - |
dc.contributor.author | 안창호 | - |
dc.contributor.author | 김정희 | - |
dc.contributor.author | 최만호 | - |
dc.date.accessioned | 2021-12-13T00:40:51Z | - |
dc.date.available | 2021-12-13T00:40:51Z | - |
dc.date.created | 2021-11-18 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82931 | - |
dc.description.abstract | Background: Conventional diagnostic approaches for adrenal tumors require multi-step processes, including imaging studies anddynamic hormone tests. Therefore, this study aimed to discriminate adrenal tumors from a single blood sample based on the combination of liquid chromatography-mass spectrometry (LC-MS) and machine learning algorithms in serum profiling of adrenal steroids. Methods: The LC-MS-based steroid profiling was applied to serum samples obtained from patients with nonfunctioning adenoma(NFA, n=73), Cushing’s syndrome (CS, n=30), and primary aldosteronism (PA, n=40) in a prospective multicenter study of adrenaldisease. The decision tree (DT), random forest (RF), and extreme gradient boost (XGBoost) were performed to categorize the subtypes of adrenal tumors. Results: The CS group showed higher serum levels of 11-deoxycortisol than the NFA group, and increased levels of tetrahydrocortisone (THE), 20α-dihydrocortisol, and 6β-hydroxycortisol were found in the PA group. However, the CS group showed lower levelsof dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEA-S) than both the NFA and PA groups. Patients with PA expressed higher serum 18-hydroxycortisol and DHEA but lower THE than NFA patients. The balanced accuracies of DT, RF, andXGBoost for classifying each type were 78%, 96%, and 97%, respectively. In receiver operating characteristics (ROC) analysis forCS, XGBoost, and RF showed a significantly greater diagnostic power than the DT. However, in ROC analysis for PA, only RF exhibited better diagnostic performance than DT. Conclusion: The combination of LC-MS-based steroid profiling with machine learning algorithms could be a promising one-stepdiagnostic approach for the classification of adrenal tumor subtypes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한내분비학회 | - |
dc.relation.isPartOf | Endocrinology and Metabolism | - |
dc.title | Metabolic Subtyping of Adrenal Tumors: Prospective Multi-Center Cohort Study in Korea | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000727577100021 | - |
dc.identifier.doi | 10.3803/EnM.2021.1149 | - |
dc.identifier.bibliographicCitation | Endocrinology and Metabolism, v.36, no.5, pp.1131 - 1141 | - |
dc.identifier.kciid | ART002771035 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85119262523 | - |
dc.citation.endPage | 1141 | - |
dc.citation.startPage | 1131 | - |
dc.citation.title | Endocrinology and Metabolism | - |
dc.citation.volume | 36 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | 이시훈 | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Steroid metabolism | - |
dc.subject.keywordAuthor | Supervised machine learning | - |
dc.subject.keywordAuthor | Adrenal neoplasms | - |
dc.subject.keywordAuthor | Cushing syndrome | - |
dc.subject.keywordAuthor | Primary hyperaldosteronism | - |
dc.subject.keywordPlus | PRIMARY ALDOSTERONISM | - |
dc.subject.keywordPlus | CUSHINGS-SYNDROME | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | 18-HYDROXYCORTISOL | - |
dc.subject.keywordPlus | 18-OXOCORTISOL | - |
dc.subject.keywordPlus | SOCIETY | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | MS/MS | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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