Suppression of Adipocyte Differentiation by Foenumoside B from Lysimachia foenum-graecum Is Mediated by PPAR. Antagonism
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwak, Hyun Jeong | - |
dc.contributor.author | Choi, Hye-Eun | - |
dc.contributor.author | Jang, Jinsun | - |
dc.contributor.author | Park, Soo Kyoung | - |
dc.contributor.author | Cho, Byoung Heon | - |
dc.contributor.author | Kim, Seul Ki | - |
dc.contributor.author | Lee, Sunyi | - |
dc.contributor.author | Kang, Nam Sook | - |
dc.contributor.author | Cheon, Hyae Gyeong | - |
dc.date.available | 2020-02-28T01:45:50Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-05-13 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8295 | - |
dc.description.abstract | Lysimachia foenum-graecum extract (LFE) and its active component foenumoside B (FSB) have been shown to inhibit adipocyte differentiation, but their mechanisms were poorly defined. Here, we investigated the molecular mechanisms responsible for their anti-adipogenic effects. Both LFE and FSB inhibited the differentiation of 3T3-L1 preadipocytes induced by peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists, accompanied by reductions in the expressions of the lipogenic genes aP2, CD36, and FAS. Moreover, LFE and FSB inhibited PPAR gamma transactivation activity with IC(50)s of 22.5 mu g/ml and 7.63 mu g/ml, respectively, and showed selectivity against PPAR alpha and PPAR delta. Rosiglitazone-induced interaction between PPAR. ligand binding domain (LBD) and coactivator SRC-1 was blocked by LFE or FSB, whereas reduced NCoR-1 binding to PPAR gamma by rosiglitazone was reversed in the presence of LFE or FSB. In vivo administration of LFE into either ob/ob mice or KKAy mice reduced body weights, and levels of PPAR gamma and C/EBP alpha in fat tissues. Furthermore, insulin resistance was ameliorated by LFE treatment, with reduced adipose tissue inflammation and hepatic steatosis. Thus, LFE and FSB were found to act as PPAR gamma antagonists that improve insulin sensitivity and metabolic profiles. We propose that LFE and its active component FSB offer a new therapeutic strategy for metabolic disorders including obesity and insulin resistance. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | GAMMA | - |
dc.subject | FAT | - |
dc.subject | COACTIVATOR | - |
dc.subject | ADIPOGENESIS | - |
dc.subject | TROGLITAZONE | - |
dc.subject | OBESITY | - |
dc.subject | ALPHA | - |
dc.subject | MOUSE | - |
dc.title | Suppression of Adipocyte Differentiation by Foenumoside B from Lysimachia foenum-graecum Is Mediated by PPAR. Antagonism | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000376589400050 | - |
dc.identifier.doi | 10.1371/journal.pone.0155432 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.11, no.5 | - |
dc.identifier.scopusid | 2-s2.0-84969753201 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 11 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Kwak, Hyun Jeong | - |
dc.contributor.affiliatedAuthor | Choi, Hye-Eun | - |
dc.contributor.affiliatedAuthor | Jang, Jinsun | - |
dc.contributor.affiliatedAuthor | Park, Soo Kyoung | - |
dc.contributor.affiliatedAuthor | Cheon, Hyae Gyeong | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordPlus | FAT | - |
dc.subject.keywordPlus | COACTIVATOR | - |
dc.subject.keywordPlus | ADIPOGENESIS | - |
dc.subject.keywordPlus | TROGLITAZONE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | MOUSE | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.