Growth factors-loaded stents modified with hyaluronic acid and heparin for induction of rapid and tight re-endothelialization
DC Field | Value | Language |
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dc.contributor.author | Choi, Dong Hoon | - |
dc.contributor.author | Kang, Sung Nam | - |
dc.contributor.author | Kim, Seong Min | - |
dc.contributor.author | Gobaa, Samy | - |
dc.contributor.author | Park, Bang Ju | - |
dc.contributor.author | Kim, Ik Hwan | - |
dc.contributor.author | Joung, Yoon Ki | - |
dc.contributor.author | Han, Dong Keun | - |
dc.date.available | 2020-02-28T01:45:55Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-05-01 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8298 | - |
dc.description.abstract | Rapid re-endothelialization of damaged vessel lining efficiently prevents restenosis and thrombosis and restores original vascular functions. In this study, we designed a novel metallic stent with a heparin-modified surface and used different methods, including 1-ethy1-3-(3-dimethylaminopropyl)carbodiimide (EDC) and divinyl sulfone (DVS), to load growth factors. First we loaded heparin into a dopamine-conjugated hyaluronic acid (HA) coating to serve as a growth factor reservoir. In a second step, we took advantage of the heparin-binding domain of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) to gain advanced re-endothelialization capabilities. We demonstrated that DVS technique offered higher amount of growth factor loading. In vitro assessment also showed better capillary-like structure formation and localized gap junctions when DVS coating was employed. This study suggested that growth factor loaded stent modified by HA and heparin provided the advantage to rapid and tight restoration of endothelium. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.subject | INTIMAL HYPERPLASIA | - |
dc.subject | ELUTING STENTS | - |
dc.subject | PROTEIN | - |
dc.subject | IMMOBILIZATION | - |
dc.subject | BIOACTIVITY | - |
dc.subject | EXPRESSION | - |
dc.subject | SURFACES | - |
dc.subject | DELIVERY | - |
dc.subject | CELLS | - |
dc.subject | MODEL | - |
dc.title | Growth factors-loaded stents modified with hyaluronic acid and heparin for induction of rapid and tight re-endothelialization | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000374197700071 | - |
dc.identifier.doi | 10.1016/j.colsurfb.2016.01.028 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.141, pp.602 - 610 | - |
dc.identifier.scopusid | 2-s2.0-84959148135 | - |
dc.citation.endPage | 610 | - |
dc.citation.startPage | 602 | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 141 | - |
dc.contributor.affiliatedAuthor | Park, Bang Ju | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Re-endothelialization | - |
dc.subject.keywordAuthor | Stent | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | Heparin | - |
dc.subject.keywordAuthor | Growth factor | - |
dc.subject.keywordAuthor | Dopamine | - |
dc.subject.keywordPlus | INTIMAL HYPERPLASIA | - |
dc.subject.keywordPlus | ELUTING STENTS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | IMMOBILIZATION | - |
dc.subject.keywordPlus | BIOACTIVITY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SURFACES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MODEL | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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