Characteristics of pediatric rhabdomyolysis and the associated risk factors for acute kidney injury: a retrospective multicenter study in Korea
- Authors
- Yoo, Sukdong; Cho, Min Hyun; Baek, Hee Sun; Song, Ji Yeon; Lee, Hye Sun; Yang, Eun Mi; Yoo, Kee Hwan; Kim, Su Jin; Shin, Jae Il; Lee, Keum Hwa; Ha, Tae-Sun; Jang, Kyung Mi; Lee, Jung Won; Kim, Kee Hyuck; Cho, Heeyeon; Lee, Mee Jeong; Suh, Jin-Soon; Han, Kyoung Hee; Hyun, Hye Sun; Ha, Il-Soo; Cheong, Hae Il; Kang, Hee Gyung; Namgoong, Mee Kyung; Cho, Hye-Kyung; Oh, Jae-Hyuk; Lee, Sang Taek; Kim, Kyo Sun; Lee, Joo Hoon; Park, Young Seo; Kim, Seong Heon
- Issue Date
- Dec-2021
- Publisher
- KOREAN SOC NEPHROLOGY
- Keywords
- Creatine kinase; Etiology; Muscles; Renal insufficiency
- Citation
- KIDNEY RESEARCH AND CLINICAL PRACTICE, v.40, no.4, pp.673 - 686
- Journal Title
- KIDNEY RESEARCH AND CLINICAL PRACTICE
- Volume
- 40
- Number
- 4
- Start Page
- 673
- End Page
- 686
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83002
- DOI
- 10.23876/j.krcp.21.051
- ISSN
- 2211-9132
- Abstract
- Background: The clinical features of pediatric rhabdomyolysis differ from those of the adults with rhabdomyolysis; however, multicenter studies are lacking. This study aimed to investigate the characteristics of pediatric rhabdomyolysis and reveal the risk factors for acute kidney injury (AKI) in such cases. Methods: This retrospective study analyzed the medical records of children and adolescents diagnosed with rhabdomyolysis at 23 hospitals in South Korea between January 2007 and December 2016. Results: Among 880 patients, those aged 3 to 5 years old composed the largest subgroup (19.4%), and all age subgroups were predominantly male. The incidence of AKI was 11.3%. Neurological disorders (53.6%) and infection (39.0%) were the most common underlying disorder and cause of rhabdomyolysis, respectively. The median age at diagnosis in the AKI subgroup was older than that in the non-AKI subgroup (12.2 years vs. 8.0 years). There were no significant differences in body mass index, myalgia, dark-colored urine, or the number of causal factors between the two AKI-status subgroups. The multivariate logistic regression model indicated that the following factors were independently associated with AKI: multiorgan failure, presence of an underlying disorder, strong positive urine occult blood, increased aspartate aminotransferase and uric acid levels, and reduced calcium levels. Conclusion: Our study revealed characteristic clinical and laboratory features of rhabdomyolysis in a Korean pediatric population and highlighted the risk factors for AKI in these cases. Our findings will contribute to a greater understanding of pediatric rhabdomyolysis and may enable early intervention against rhabdomyolysis-induced AKI.
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