The protective effect of hamamelis virginiana stem and leaf extract on fine dust-induced damage on human keratinocytes
DC Field | Value | Language |
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dc.contributor.author | Choi, Jiyoung | - |
dc.contributor.author | Yang, Dongki | - |
dc.contributor.author | Moon, Mi Yeon | - |
dc.contributor.author | Han, Gi Yeon | - |
dc.contributor.author | Chang, Moon Sik. | - |
dc.contributor.author | Cha, Joonseok | - |
dc.date.accessioned | 2022-01-03T00:40:20Z | - |
dc.date.available | 2022-01-03T00:40:20Z | - |
dc.date.created | 2022-01-03 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2079-9284 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83105 | - |
dc.description.abstract | Witch hazel extracts have been used for decades as cosmetic ingredients in skin care products. Our present study aims to evaluate its potential in anti-pollution products using a previously reported in vitro model. Calcium is a universal second messenger, and we used human respiratory and skin cells to detect changes in intracellular Ca2+ concentrations upon particulate matter contact. Both an increase in pro-inflammatory markers and a decrease in tight junction proteins were confirmed, as previously reported. Witch hazel stem and leaf extract showed significant attenuation of Ca2+ response upon the challenge; it displayed systematic regulations of the signal generator, PAR-2; a pro-inflammatory marker, NF-κB; and a tight junction protein, Occludin. We identified hexagalloylglucose from the extract and concluded that it is a major component regulating protection from particulate matter. Based on these results, witch hazel extract containing hexagalloylglucose is an active ingredient in anti-pollution skin care products. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | Cosmetics | - |
dc.title | The protective effect of hamamelis virginiana stem and leaf extract on fine dust-induced damage on human keratinocytes | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000736257300001 | - |
dc.identifier.doi | 10.3390/cosmetics8040119 | - |
dc.identifier.bibliographicCitation | Cosmetics, v.8, no.4 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85121774120 | - |
dc.citation.title | Cosmetics | - |
dc.citation.volume | 8 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Yang, Dongki | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Keratinocyte | - |
dc.subject.keywordAuthor | Particulate matter | - |
dc.subject.keywordAuthor | Skin barrier | - |
dc.subject.keywordAuthor | Witch hazel | - |
dc.subject.keywordPlus | BARK | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | PROANTHOCYANIDINS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | DISTILLATE | - |
dc.subject.keywordPlus | TANNINS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.description.journalRegisteredClass | scopus | - |
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