Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sanjay | - |
dc.contributor.author | Sharma, Anshul | - |
dc.contributor.author | Lee, Hae-Jeung | - |
dc.date.accessioned | 2022-01-07T01:40:39Z | - |
dc.date.available | 2022-01-07T01:40:39Z | - |
dc.date.created | 2022-01-07 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83150 | - |
dc.description.abstract | Peroxisome proliferator-activated receptors (PPAR-gamma, PPAR-alpha, and PPAR-beta/delta) are ligand-dependent nuclear receptors that play a critical role in the regulation of hundreds of genes through their activation. Their expression and targeted activation play an important role in the treatment of a variety of diseases, including neurodegenerative, cardiovascular, diabetes, and cancer. In recent years, several reviews have been published describing the therapeutic potential of PPAR agonists (natural or synthetic) in the disorders listed above; however, no comprehensive report defining the role of naturally derived phytoconstituents as PPAR agonists targeting neurodegenerative diseases has been published. This review will focus on the role of phytoconstituents as PPAR agonists and the relevant preclinical studies and mechanistic insights into their neuroprotective effects. Exemplary research includes flavonoids, fatty acids, cannabinoids, curcumin, genistein, capsaicin, and piperine, all of which have been shown to be PPAR agonists either directly or indirectly. Additionally, a few studies have demonstrated the use of clinical samples in in vitro investigations. The role of the fruit fly Drosophila melanogaster as a potential model for studying neurodegenerative diseases has also been highlighted. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | BIOMEDICINES | - |
dc.title | Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000736171700001 | - |
dc.identifier.doi | 10.3390/biomedicines9121914 | - |
dc.identifier.bibliographicCitation | BIOMEDICINES, v.9, no.12 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85123001480 | - |
dc.citation.title | BIOMEDICINES | - |
dc.citation.volume | 9 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Sanjay | - |
dc.contributor.affiliatedAuthor | Sharma, Anshul | - |
dc.contributor.affiliatedAuthor | Lee, Hae-Jeung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | neurodegenerative disorders | - |
dc.subject.keywordAuthor | PPARs | - |
dc.subject.keywordAuthor | phytoconstituents | - |
dc.subject.keywordAuthor | bioactivities | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Parkinson disease | - |
dc.subject.keywordAuthor | Huntington disease | - |
dc.subject.keywordPlus | PROLIFERATOR-ACTIVATED-RECEPTOR | - |
dc.subject.keywordPlus | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject.keywordPlus | POLYUNSATURATED FATTY-ACIDS | - |
dc.subject.keywordPlus | NUCLEAR HORMONE-RECEPTORS | - |
dc.subject.keywordPlus | RETINOID-X-RECEPTORS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | DOCOSAHEXAENOIC ACID | - |
dc.subject.keywordPlus | GAMMA AGONISTS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.