A systematic review on the modifications of extracellular vesicles: a revolutionized tool of nano-biotechnology
DC Field | Value | Language |
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dc.contributor.author | Raghav, Alok | - |
dc.contributor.author | Jeong, Goo-Bo | - |
dc.date.accessioned | 2022-01-08T06:40:54Z | - |
dc.date.available | 2022-01-08T06:40:54Z | - |
dc.date.created | 2022-01-08 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1477-3155 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83191 | - |
dc.description.abstract | Background: Tailoring extracellular vesicles (EVs) can bequeath them with diverse functions and efficient performance in nano-biotechnology. Engineering and modification of EVs improves the targeted drug delivery efficiency. Here, we performed systematic review of various methods for EVs modifications. Methods: PubMed, Scopus, ISI Web of Science, EMBASE, and Google Scholar were searched for available articles on EVs modifications (up to March 2021). In total, 1208 articles were identified and assessed, and then only 36 articles were found eligible and included. Results: Six studies demonstrate the application of click chemistry, seven studies used co-incubation, two studies used chemical transfection, four studies implicated electroporation and sonication approach for modification of EVs. Moreover, two studies utilized microfluidics as suitable approach for loading cargo into EVs, while eight studies showed freeze-thaw method as feasible for these biological nanoparticles. Conclusion: Freeze-thaw approach is found to be convenient and popular among researchers for performing modifications in EVs for the purpose of targeted drug delivery loading. Clinical-grade EVs production with good clinical practices (GCPs) is challenging in the current scenario. More studies are needed to determine the best suitable approach for cargo loading of EVs that may be exploited for research and therapeutic use. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.relation.isPartOf | JOURNAL OF NANOBIOTECHNOLOGY | - |
dc.title | A systematic review on the modifications of extracellular vesicles: a revolutionized tool of nano-biotechnology | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000736712900001 | - |
dc.identifier.doi | 10.1186/s12951-021-01219-2 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOBIOTECHNOLOGY, v.19, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85122074547 | - |
dc.citation.title | JOURNAL OF NANOBIOTECHNOLOGY | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Jeong, Goo-Bo | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Synthesis | - |
dc.subject.keywordAuthor | Extracellular vesicles | - |
dc.subject.keywordAuthor | Nano-biotechnology | - |
dc.subject.keywordAuthor | Tailoring | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordAuthor | Systematic review | - |
dc.subject.keywordPlus | DRUG-DELIVERY VEHICLES | - |
dc.subject.keywordPlus | CELL-DERIVED EXOSOMES | - |
dc.subject.keywordPlus | MICROVESICLES | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | SIRNA | - |
dc.subject.keywordPlus | NANOVESICLES | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | RNA | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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