Characterization of focal hypermetabolic thyroid incidentaloma: An analysis with F-18 fluorodeoxyglucose positron emission tomography/computed tomography parameters
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Haejun | - |
dc.contributor.author | Chung, Yoo Seung | - |
dc.contributor.author | Lee, Joon-Hyop | - |
dc.contributor.author | Lee, Ki-Young | - |
dc.contributor.author | Hwang, Kyung-Hoon | - |
dc.date.accessioned | 2022-01-10T15:40:13Z | - |
dc.date.available | 2022-01-10T15:40:13Z | - |
dc.date.created | 2022-01-11 | - |
dc.date.issued | 2022-01-07 | - |
dc.identifier.issn | 2307-8960 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83218 | - |
dc.description.abstract | BACKGROUND Incidentally found thyroid tumor (thyroid incidentaloma, TI) on F-18 fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) is reported in 2.5%-5% of patients being investigated for non-thyroid purposes. Up to 50% of these cases have been diagnosed to be malignant by cytological/histological results. Ultrasonography (US) and fine-needle aspiration cytology are recommended for thyroid nodules with high FDG uptake (hypermetabolism) that are 1 cm or greater in size. It is important to accurately determine whether a suspicious hypermetabolic TI is malignant or benign. AIM To distinguish malignant hypermetabolic TIs from benign disease by analyzing F-18 FDG PET-CT parameters and to identify a cut-off value. METHODS Totally, 12761 images of patients who underwent F-18 FDG PET-CT for nonthyroid purposes at our hospital between January 2016 and December 2020 were retrospectively reviewed, and 339 patients [185 men (mean age: 68 ± 11.2) and 154 women (mean age: 63 ± 15.0)] were found to have abnormal, either focal or diffuse, thyroid FDG uptake. After a thorough review of their medical records, US, and cytological/histological reports, 46 eligible patients with focal hyper-metabolic TI were included in this study. The TIs were categorized as malignant and benign according to the cytological/histological reports, and four PET parameters [standardized uptake value (SUV)max, SUVpeak, SUVmean, and metabolic tumor volume (MTV)] were measured on FDG PET-CT. Total lesion glycolysis (TLG) was calculated by multiplying the SUVmean by MTV. Both parametric and non-parametric methods were used to compare the five parameters between malignant and benign lesions. Receiver operating characteristic (ROC) curve analysis was performed to identify a cut-off value. RESULTS Each of the 46 patients [12 men (26.1%; mean age: 62 ± 13.1 years) and 34 women (73.9%; mean age: 60 ± 12.0 years)] with focal hypermetabolic TIs had one focal hypermetabolic TI. Among them, 26 (56.5%) were malignant and 20 (43.5%) were benign. SUVmax, SUVpeak, SUVmean, and TLG were all higher in malignant lesions than benign ones, but the difference was statistically significant (P = 0.012) only for SUVmax. There was a positive linear correlation (r = 0.339) between SUVmax and the diagnosis of malignancy. ROC curve analysis for SUVmax revealed an area under the curve of 0.702 (P < 0.05, 95% confidence interval: 0.550-0.855) and SUVmax cut-off of 8.5 with a sensitivity of 0.615 and a specificity of 0.789. CONCLUSION More than half of focal hypermetabolic TIs on F-18 FDG PET-CT were revealed as malignant lesions, and SUVmax was the best parameter for discriminating between malignant and benign disease. Unexpected focal hypermetabolic TIs with the SUVmax above the cut-off value of 8.5 may have a greater than 70% chance of malignancy; therefore, further active assessment is required. © 2022. The Author(s). Published by Baishideng Publishing Group Inc. All Rights Reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Baishideng Publishing Group Co. Limited | - |
dc.relation.isPartOf | World Journal of Clinical Cases | - |
dc.title | Characterization of focal hypermetabolic thyroid incidentaloma: An analysis with F-18 fluorodeoxyglucose positron emission tomography/computed tomography parameters | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000763121300016 | - |
dc.identifier.doi | 10.12998/wjcc.v10.i1.155 | - |
dc.identifier.bibliographicCitation | World Journal of Clinical Cases, v.10, no.1, pp.155 - 165 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85122571705 | - |
dc.citation.endPage | 165 | - |
dc.citation.startPage | 155 | - |
dc.citation.title | World Journal of Clinical Cases | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Lee, Haejun | - |
dc.contributor.affiliatedAuthor | Chung, Yoo Seung | - |
dc.contributor.affiliatedAuthor | Lee, Joon-Hyop | - |
dc.contributor.affiliatedAuthor | Lee, Ki-Young | - |
dc.contributor.affiliatedAuthor | Hwang, Kyung-Hoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Cut-off | - |
dc.subject.keywordAuthor | Fluorodeoxyglucose positron emission tomography/computed tomography | - |
dc.subject.keywordAuthor | Malignancy | - |
dc.subject.keywordAuthor | Standardized uptake value | - |
dc.subject.keywordAuthor | Thyroid incidentaloma | - |
dc.subject.keywordPlus | CLINICAL-SIGNIFICANCE | - |
dc.subject.keywordPlus | NODULE SIZE | - |
dc.subject.keywordPlus | ELEVATED THYROGLOBULIN | - |
dc.subject.keywordPlus | DIAGNOSTIC-VALUE | - |
dc.subject.keywordPlus | HURTHLE CELL | - |
dc.subject.keywordPlus | BODY SCAN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PET/CT | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.