Real-World Long-Term Clinical Outcomes of Ultrathin Strut Biodegradable Polymer Drug-Eluting Stents in Korean ST-Segment-Elevation Myocardial Infarction (STEMI) Patients with or without Acute Heart Failure Undergoing Primary Percutaneous Coronary Intervention
DC Field | Value | Language |
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dc.contributor.author | Jang, Albert Youngwoo | - |
dc.contributor.author | Yu, Jongwook | - |
dc.contributor.author | Oh, Pyung Chun | - |
dc.contributor.author | Kim, Minsu | - |
dc.contributor.author | Suh, Soon Yong | - |
dc.contributor.author | Lee, Kyounghoon | - |
dc.contributor.author | Han, Seung Hwan | - |
dc.contributor.author | Kang, Woong Chol | - |
dc.date.accessioned | 2022-01-10T23:41:01Z | - |
dc.date.available | 2022-01-10T23:41:01Z | - |
dc.date.created | 2021-12-19 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83231 | - |
dc.description.abstract | Biodegradable polymers (BDPs) and ultrathin struts were recently introduced to drug-eluting stents (DES) to further improve outcomes. In this study, we analyzed and compared the effect of the ultrathin strut BDP-DES (UBDP-DES) with the conventional durable polymer-DES (DP-DES) in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PPCI). A total of 356 STEMI patients (n = 160 in the UBDP-DES group and n = 196 in the DP-DES group) were enrolled. The primary endpoint was target lesion failure (TLF), including cardiac death, target vessel myocardial infarction, and ischemic-driven, target lesion revascularization (ID-TLR). The mean age was 60.3 ± 12.7 years (male 81.7%), and the median follow-up duration was 63.8 months. TLF was numerically more frequent in the UBDP-DES group (8.1% vs. 4.1%; HR 2.14; 95% CI 0.89–5.18; p = 0.091). Propensity score matching (PSM) was performed to balance discrepancies in the baseline characteristics due to patients in the UBDP-DES group initially having more unstable vital signs. However, after PSM (n = 116 in each group), there was no significant difference in TLF (5.3% vs. 5.3%; HR 1.04, 95% CI 0.34-3.22; p = 0.947) or other secondary endpoints including ID-TLR. In the subgroup analysis, subjects with initial acute heart failure (AHF), defined as Killip class ≥ 3, were associated with 13.6% chance of 30-day mortality (9-fold of those without AHF), although chances of repeat revascularization were low (3.0%). Among patients with AHF, the UBDP-DES group was associated with a numerically higher chance of TLF compared with the DP-DES group. There was no difference in TLF between groups in patients without AHF. This study showed that UBDP-DES has long-term clinical outcomes similar to those of conventional DP-DES in real-world Korean STEMI patients receiving PPCI, especially in those without initial AHF. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | Journal of Clinical Medicine | - |
dc.title | Real-World Long-Term Clinical Outcomes of Ultrathin Strut Biodegradable Polymer Drug-Eluting Stents in Korean ST-Segment-Elevation Myocardial Infarction (STEMI) Patients with or without Acute Heart Failure Undergoing Primary Percutaneous Coronary Intervention | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000738988500001 | - |
dc.identifier.doi | 10.3390/jcm10245898 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Medicine, v.10, no.24 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85121039184 | - |
dc.citation.title | Journal of Clinical Medicine | - |
dc.citation.volume | 10 | - |
dc.citation.number | 24 | - |
dc.contributor.affiliatedAuthor | Jang, Albert Youngwoo | - |
dc.contributor.affiliatedAuthor | Oh, Pyung Chun | - |
dc.contributor.affiliatedAuthor | Kim, Minsu | - |
dc.contributor.affiliatedAuthor | Suh, Soon Yong | - |
dc.contributor.affiliatedAuthor | Lee, Kyounghoon | - |
dc.contributor.affiliatedAuthor | Han, Seung Hwan | - |
dc.contributor.affiliatedAuthor | Kang, Woong Chol | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Acute heart failure | - |
dc.subject.keywordAuthor | Biodegradable polymer | - |
dc.subject.keywordAuthor | Durable polymer | - |
dc.subject.keywordAuthor | Real-world | - |
dc.subject.keywordAuthor | STEMI | - |
dc.subject.keywordAuthor | Ultrathin strut | - |
dc.subject.keywordPlus | DURABLE POLYMER | - |
dc.subject.keywordPlus | LEADERS | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | REVASCULARIZATION | - |
dc.subject.keywordPlus | THROMBOSIS | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | COVERAGE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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