Short-course radiotherapy and chemotherapy for conversion surgery in patients with unresectable metastatic rectal cancer:a preliminary case series study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Youngbae Jeon | - |
dc.contributor.author | Kyoung-Won Han | - |
dc.contributor.author | Seok Ho Lee | - |
dc.contributor.author | Sun Jin Sym | - |
dc.contributor.author | Seung Joon Choi | - |
dc.contributor.author | Seung Yeon Ha | - |
dc.contributor.author | Jeong-Heum Baek | - |
dc.date.accessioned | 2022-01-13T02:41:11Z | - |
dc.date.available | 2022-01-13T02:41:11Z | - |
dc.date.created | 2022-01-13 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2288-4084 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83248 | - |
dc.description.abstract | Purpose: Curative treatment is challenging in patients with locally advanced rectal cancer and unresectable metastases. The aim of this study was to evaluate the clinical outcomes of short-course radiotherapy (RT) followed by systemic chemotherapy for patients with rectal cancer with mesorectal fascia (MRF) involvement and unresectable distant metastases. Methods: The study included consecutive patients diagnosed as having metastatic mid-to-low rectal cancer treated with short-course RT followed by systemic chemotherapy for conversion radical or palliative surgery between 2014 and 2019 at Gil Medical Center. The patients had primary rectal tumors involving the MRF and unresectable distant metastases. The treatment strategies were determined in a multidisci plinary team discussion. Results: Seven patients (five men and two women) underwent short-course RT (5×5 Gy) and preoperative systemic chemotherapy. The me dian age was 68 years (range, 46–84 years), and the median distance from the anal verge to the primary tumor was 6.0 cm (range, 2.0–9.0 cm). During the median follow-up period of 29.4 months, three patients underwent conversion radical surgery with R0 resection, two under went palliative surgery, and two could not undergo surgery. No postoperative major morbidity or mortality occurred. The patients who under went conversion complete radical surgery showed good long-term survival outcomes, with an overall survival time of 29.4–48.8 months and progression-free survival time of 14.7–41.1 months. Conclusion: Short-course RT followed by systemic chemotherapy could provide patients with unresectable stage IV rectal cancer a chance to undergo to conversion radical surgery with good long-term survival outcomes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한종양외과학회 | - |
dc.relation.isPartOf | 대한종양외과학회지 | - |
dc.title | Short-course radiotherapy and chemotherapy for conversion surgery in patients with unresectable metastatic rectal cancer:a preliminary case series study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한종양외과학회지, v.17, no.2, pp.111 - 116 | - |
dc.identifier.kciid | ART002801307 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 116 | - |
dc.citation.startPage | 111 | - |
dc.citation.title | 대한종양외과학회지 | - |
dc.citation.volume | 17 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Youngbae Jeon | - |
dc.contributor.affiliatedAuthor | Kyoung-Won Han | - |
dc.contributor.affiliatedAuthor | Seok Ho Lee | - |
dc.contributor.affiliatedAuthor | Sun Jin Sym | - |
dc.contributor.affiliatedAuthor | Seung Joon Choi | - |
dc.contributor.affiliatedAuthor | Seung Yeon Ha | - |
dc.contributor.affiliatedAuthor | Jeong-Heum Baek | - |
dc.subject.keywordAuthor | Keywords: Radiotherapy | - |
dc.subject.keywordAuthor | Rectal cancer | - |
dc.subject.keywordAuthor | Metastasis | - |
dc.subject.keywordAuthor | Surger | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.