Decreased regional gray matter volume in suicide attempters compared to suicide non-attempters with major depressive disorders
DC Field | Value | Language |
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dc.contributor.author | Lee, Yu Jin | - |
dc.contributor.author | Kim, Soohyun | - |
dc.contributor.author | Gwak, Ah Reum | - |
dc.contributor.author | Kim, Seog Ju | - |
dc.contributor.author | Kang, Seung-Gul | - |
dc.contributor.author | Na, Kyoung-Sae | - |
dc.contributor.author | Son, Young-Don | - |
dc.contributor.author | Park, Juhyun | - |
dc.date.available | 2020-02-28T01:46:22Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 0010-440X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8326 | - |
dc.description.abstract | Objective: This study investigated regional gray matter (GM) volume differences between suicide attempters and suicide non-attempters with major depressive disorder (MDD) and their relationship with psychological risk factors for suicidality. Methods: MDD patients with and without a suicide attempt history (n = 19 in each group) participated. The Hamilton Depression Rating Scale, Clinical Global Impression (severity subscale), Scale for Suicide Ideation (SSI), Risk-Rescue Rating (RRR), Beck Hopelessness Scale (BHS), Barrett Impulsivity Scale, Eysenck Personality Questionnaire, and Ways of Coping Checklist (WCCL) were administered. T1-weighted structural magnetic resonance imaging scans were acquired to evaluate changes in GM volume. Voxel-based morphometry was performed using the SPM 8 software package. Two-sample t-tests were used during second-level group comparison analysis; partial correlation analysis controlling for gender and age identified associations between regional GM volume and psychological measures. Results: Suicide attempters exhibited significantly decreased GM volume in the left angular gyms (p < 0.001, uncorrected) and right cerebellum (p < 0.001, uncorrected). GM volume in the left angular gyms was inversely correlated with BHS scores (r = -0.55, p < 0.01) and positively correlated with the Seeking Social Support subscale of the WCCL (r = 0.43, p < 0.01). Conclusion: These fmdings provide evidence of a neural basis of suicidal behaviors in MDD. In particular, reduced GM volume in the left angular gyms may be a neurobiological marker of suicidality in depressed patients. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.relation.isPartOf | COMPREHENSIVE PSYCHIATRY | - |
dc.subject | RISK-FACTORS | - |
dc.subject | PSYCHOLOGICAL AUTOPSY | - |
dc.subject | CLINICAL PREDICTORS | - |
dc.subject | SCALE | - |
dc.subject | ABNORMALITIES | - |
dc.subject | VULNERABILITY | - |
dc.subject | EXPERIENCE | - |
dc.subject | HISTORY | - |
dc.subject | MRI | - |
dc.title | Decreased regional gray matter volume in suicide attempters compared to suicide non-attempters with major depressive disorders | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000375173300010 | - |
dc.identifier.doi | 10.1016/j.comppsych.2016.02.013 | - |
dc.identifier.bibliographicCitation | COMPREHENSIVE PSYCHIATRY, v.67, pp.59 - 65 | - |
dc.identifier.scopusid | 2-s2.0-84960912597 | - |
dc.citation.endPage | 65 | - |
dc.citation.startPage | 59 | - |
dc.citation.title | COMPREHENSIVE PSYCHIATRY | - |
dc.citation.volume | 67 | - |
dc.contributor.affiliatedAuthor | Kang, Seung-Gul | - |
dc.contributor.affiliatedAuthor | Na, Kyoung-Sae | - |
dc.contributor.affiliatedAuthor | Son, Young-Don | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | PSYCHOLOGICAL AUTOPSY | - |
dc.subject.keywordPlus | CLINICAL PREDICTORS | - |
dc.subject.keywordPlus | SCALE | - |
dc.subject.keywordPlus | ABNORMALITIES | - |
dc.subject.keywordPlus | VULNERABILITY | - |
dc.subject.keywordPlus | EXPERIENCE | - |
dc.subject.keywordPlus | HISTORY | - |
dc.subject.keywordPlus | MRI | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
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