Drug Resistance Reversal Potential of Nanoparticles/Nanocomposites via Antibiotic's Potentiation in Multi Drug Resistant P. aeruginosa
DC Field | Value | Language |
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dc.contributor.author | Pandey, Pratima | - |
dc.contributor.author | Sahoo, Rajashree | - |
dc.contributor.author | Singh, Khusbu | - |
dc.contributor.author | Pati, Sanghamitra | - |
dc.contributor.author | Mathew, Jose | - |
dc.contributor.author | Pandey, Avinash Chandra | - |
dc.contributor.author | Kant, Rajni | - |
dc.contributor.author | Han, Ihn | - |
dc.contributor.author | Choi, Eun-Ha | - |
dc.contributor.author | Dwivedi, Gaurav Raj | - |
dc.contributor.author | Yadav, Dharmendra K. | - |
dc.date.accessioned | 2022-01-18T00:40:16Z | - |
dc.date.available | 2022-01-18T00:40:16Z | - |
dc.date.created | 2022-01-18 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 2079-4991 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83278 | - |
dc.description.abstract | Bacteria employ numerous resistance mechanisms against structurally distinct drugs by the process of multidrug resistance. A study was planned to discover the antibacterial potential of a graphene oxide nanosheet (GO), a graphene oxide-zinc oxide nanocomposite (GO/ZnO), a graphene oxide-chitosan nanocomposite (GO-CS), a zinc oxide decorated graphene oxide-chitosan nanocomposite (GO-CS/ZnO), and zinc oxide nanoparticles (ZnO) alone and in a blend with antibiotics against a PS-2 isolate of Pseudomonas aeruginosa. These nanocomposites reduced the MIC of tetracycline (TET) from 16 folds to 64 folds against a multidrug-resistant clinical isolate. Efflux pumps were interfered, as evident by an ethidium bromide synergy study with nanocomposites, as well as inhibiting biofilm synthesis. These nanoparticles/nanocomposites also decreased the mutant prevention concentration (MPC) of TET. To the best of our knowledge, this is the first report on nanomaterials as a synergistic agent via inhibition of efflux and biofilm synthesis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | NANOMATERIALS | - |
dc.title | Drug Resistance Reversal Potential of Nanoparticles/Nanocomposites via Antibiotic's Potentiation in Multi Drug Resistant P. aeruginosa | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000741174600001 | - |
dc.identifier.doi | 10.3390/nano12010117 | - |
dc.identifier.bibliographicCitation | NANOMATERIALS, v.12, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85121878145 | - |
dc.citation.title | NANOMATERIALS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Yadav, Dharmendra K. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | nanoparticle | - |
dc.subject.keywordAuthor | nanocomposite | - |
dc.subject.keywordAuthor | drug resistance reversal | - |
dc.subject.keywordAuthor | MIC | - |
dc.subject.keywordAuthor | graphene oxide-chitosan | - |
dc.subject.keywordPlus | ANTIMICROBIAL RESISTANCE | - |
dc.subject.keywordPlus | EFFLUX PUMPS | - |
dc.subject.keywordPlus | BIOFILM FORMATION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | PORINS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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