Structural Confirmation of Lymphatic Outflow from Subconjunctival Blebs of Live Humans
DC Field | Value | Language |
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dc.contributor.author | Lee, Jong Yeon | - |
dc.contributor.author | Heilweil, Gad | - |
dc.contributor.author | Le, Phuc | - |
dc.contributor.author | Saraswathy, Sindhu | - |
dc.contributor.author | Hong, Young-Kwon | - |
dc.contributor.author | Girkin, Christopher A. | - |
dc.contributor.author | Huang, Alex S. | - |
dc.date.accessioned | 2022-01-19T06:40:21Z | - |
dc.date.available | 2022-01-19T06:40:21Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2666-9145 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83293 | - |
dc.description.abstract | Purpose To uncover the mechanism of subconjunctival outflow in humans. Design Cross-sectional study. Participants Fifteen patients receiving subconjunctival anesthesia before intravitreal injection for routine clinical care. Methods Anterior segment (AS) OCT was performed in patients with various instances of conjunctival edema or subconjunctival fluid. Other patients received a subconjunctival mixture of 0.005% indocyanine green and 2% lidocaine. After subconjunctival injection of the tracer and anesthetic mixture, blebs and associated outflow pathways were imaged angiographically and the time for appearance was recorded. The pattern and structure of outflow pathways were studied using AS OCT. Angiographic and AS OCT results were compared with trabecular and conventional outflow imaging, which demonstrates veins. Main Outcome Measures Ocular surface lymphangiography and AS OCT images. Results Anterior segment OCT of the conjunctiva in a normal eye demonstrated thin nonedematous conjunctiva with absent intraconjunctival lumens or subconjunctival fluid. Patients with a history of trabeculectomy, subconjunctival drug injection, or chemosis demonstrated thickened conjunctiva and intraconjunctival luminal pathways that contained valve-like structures. Tracer-based studies in patients demonstrated blebs with irregular subconjunctival bleb-related outflow patterns that arose in a time-dependent fashion. These angiographic pathways were luminal on OCT, sausage shaped, and contained intraluminal valve-like structures. This was in contrast to trabecular and conventional outflow imaging, where pathways were classically Y-shaped, of even caliber, and lacked valve-like structures. Conclusions Outflow pathways were seen in patients with conjunctival edema and after subconjunctival tracer injection. These pathways were lymphatic based on pattern and structural study. Better understanding of bleb-related lymphatic outflow may lead to improved bleb-requiring glaucoma surgeries and subconjunctival drug delivery. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Inc. | - |
dc.relation.isPartOf | Ophthalmology Science | - |
dc.title | Structural Confirmation of Lymphatic Outflow from Subconjunctival Blebs of Live Humans | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.1016/j.xops.2021.100080 | - |
dc.identifier.bibliographicCitation | Ophthalmology Science, v.1, no.4 | - |
dc.description.isOpenAccess | N | - |
dc.citation.title | Ophthalmology Science | - |
dc.citation.volume | 1 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Lee, Jong Yeon | - |
dc.subject.keywordAuthor | Aqueous outflow | - |
dc.subject.keywordAuthor | Blebs | - |
dc.subject.keywordAuthor | Conjunctiva | - |
dc.subject.keywordAuthor | Glaucoma surgery | - |
dc.subject.keywordAuthor | Lymphatics | - |
dc.subject.keywordAuthor | Subconjunctival | - |
dc.description.journalRegisteredClass | other | - |
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