Chemical Exchanges between Multilateral Symbionts
- Authors
- Bae, Munhyung; Mevers, Emily; Pishchany, Gleb; Whaley, Sarah G.; Rock, Charles O.; Andes, David R.; Currie, Cameron R.; Pupo, Monica T.; Clardy, Jon
- Issue Date
- Mar-2021
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v.23, no.5, pp.1648 - 1652
- Journal Title
- ORGANIC LETTERS
- Volume
- 23
- Number
- 5
- Start Page
- 1648
- End Page
- 1652
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83298
- DOI
- 10.1021/acs.orglett.1c00068
- ISSN
- 1523-7060
- Abstract
- Herein is a report on the molecular exchange occurring between multilateral symbiosis partners-a tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis.
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Collections - 약학대학 > 약학과 > 1. Journal Articles
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