Rhizolutin, a Novel 7/10/6-Tricyclic Dilactone, Dissociates Misfolded Protein Aggregates and Reduces Apoptosis/Inflammation Associated with Alzheimer's Disease
DC Field | Value | Language |
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dc.contributor.author | Kwon, Yun | - |
dc.contributor.author | Shin, Jisu | - |
dc.contributor.author | Nam, Kwangho | - |
dc.contributor.author | An, Joon Soo | - |
dc.contributor.author | Yang, Seung-Hoon | - |
dc.contributor.author | Hong, Seong-Heon | - |
dc.contributor.author | Bae, Munhyung | - |
dc.contributor.author | Moon, Kyuho | - |
dc.contributor.author | Cho, Yakdol | - |
dc.contributor.author | Woo, Jiwan | - |
dc.contributor.author | Park, Keunwan | - |
dc.contributor.author | Kim, Kyeonghwan | - |
dc.contributor.author | Shin, Jongheon | - |
dc.contributor.author | Kim, Byung-Yong | - |
dc.contributor.author | Kim, YoungSoo | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.date.accessioned | 2022-01-19T06:40:55Z | - |
dc.date.available | 2022-01-19T06:40:55Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83300 | - |
dc.description.abstract | Rhizolutin (1) was discovered as a natural product of ginseng-rhizosphericStreptomycessp. WON17. Its structure features an unprecedented 7/10/6-tricyclic dilactone carbon skeleton composed of dimethylcyclodecatriene flanked by a 7-membered and a 6-membered lactone ring based on spectroscopic analysis. During an unbiased screening of natural product libraries, this novel compound was found to dissociate amyloid-beta (A beta) plaques and tau tangles, which are key pathological hallmarks of Alzheimer's disease (AD). Rhizolutin treatment of APP/PS1 double transgenic mice with AD significantly dissociated hippocampal plaques. In vitro, rhizolutin substantially decreased A beta-induced apoptosis and inflammation in neuronal and glial cells. Our findings introduce a unique chemical entity that targets A beta and tau concurrently by mimicking misfolded protein clearance mechanisms of immunotherapy, which is prominently investigated in clinical trials. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.title | Rhizolutin, a Novel 7/10/6-Tricyclic Dilactone, Dissociates Misfolded Protein Aggregates and Reduces Apoptosis/Inflammation Associated with Alzheimer's Disease | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000574855300001 | - |
dc.identifier.doi | 10.1002/anie.202009294 | - |
dc.identifier.bibliographicCitation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.59, no.51, pp.22994 - 22998 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85091715584 | - |
dc.citation.endPage | 22998 | - |
dc.citation.startPage | 22994 | - |
dc.citation.title | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.citation.volume | 59 | - |
dc.citation.number | 51 | - |
dc.contributor.affiliatedAuthor | Bae, Munhyung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | amyloid beta | - |
dc.subject.keywordAuthor | lactones | - |
dc.subject.keywordAuthor | natural products | - |
dc.subject.keywordAuthor | tau protein | - |
dc.subject.keywordPlus | THERMOCHEMISTRY | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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