Donghaecyclinones A-C: New Cytotoxic Rearranged Angucyclinones from a Volcanic Island-Derived Marine Streptomyces sp.
DC Field | Value | Language |
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dc.contributor.author | Bae, Munhyung | - |
dc.contributor.author | An, Joon Soo | - |
dc.contributor.author | Hong, Seong-Heon | - |
dc.contributor.author | Bae, Eun Seo | - |
dc.contributor.author | Chung, Beomkoo | - |
dc.contributor.author | Kwon, Yun | - |
dc.contributor.author | Hong, Suckchang | - |
dc.contributor.author | Oh, Ki-Bong | - |
dc.contributor.author | Shin, Jongheon | - |
dc.contributor.author | Lee, Sang Kook | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.date.accessioned | 2022-01-19T06:41:01Z | - |
dc.date.available | 2022-01-19T06:41:01Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83301 | - |
dc.description.abstract | Chemical profiling of the Streptomyces sp. strain SUD119, which was isolated from a marine sediment sample collected from a volcanic island in Korea, led to the discovery of three new metabolites: donghaecyclinones A-C (1-3). The structures of 1-3 were found to be rearranged, multicyclic, angucyclinone-class compounds according to nuclear magnetic resonance (NMR) and mass spectrometry (MS) analyses. The configurations of their stereogenic centers were successfully assigned using a combination of quantum mechanics-based computational methods for calculating the NMR shielding tensor (DP4 and CP3) as well as electronic circular dichroism (ECD) along with a modified version of Mosher's method. Donghaecyclinones A-C (1-3) displayed cytotoxicity against diverse human cancer cell lines (IC50: 6.7-9.6 mu M for 3). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MARINE DRUGS | - |
dc.title | Donghaecyclinones A-C: New Cytotoxic Rearranged Angucyclinones from a Volcanic Island-Derived Marine Streptomyces sp. | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000518664600052 | - |
dc.identifier.doi | 10.3390/md18020121 | - |
dc.identifier.bibliographicCitation | MARINE DRUGS, v.18, no.2 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85079770522 | - |
dc.citation.title | MARINE DRUGS | - |
dc.citation.volume | 18 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Bae, Munhyung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | molecular modeling | - |
dc.subject.keywordAuthor | electronic circular dichroism | - |
dc.subject.keywordAuthor | quantum mechanics-based computation | - |
dc.subject.keywordAuthor | angucyclinone | - |
dc.subject.keywordAuthor | Streptomyces | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordPlus | CIRCULAR-DICHROISM | - |
dc.subject.keywordPlus | ABSOLUTE-CONFIGURATION | - |
dc.subject.keywordPlus | NMR-SPECTROSCOPY | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | DIASTEREOISOMERS | - |
dc.subject.keywordPlus | OHMYUNGSAMYCINS | - |
dc.subject.keywordPlus | STEREOCHEMISTRY | - |
dc.subject.keywordPlus | ASSIGNMENT | - |
dc.subject.keywordPlus | RESOURCE | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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