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WS9326H, an Antiangiogenic Pyrazolone-Bearing Peptide from an Intertidal Mudflat Actinomycete
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bae, Munhyung | - |
| dc.contributor.author | Oh, Jedo | - |
| dc.contributor.author | Bae, Eun Seo | - |
| dc.contributor.author | Oh, Joonseok | - |
| dc.contributor.author | Hur, Joonseong | - |
| dc.contributor.author | Suh, Young-Ger | - |
| dc.contributor.author | Lee, Sang Kook | - |
| dc.contributor.author | Shin, Jongheon | - |
| dc.contributor.author | Oh, Dong-Chan | - |
| dc.date.accessioned | 2022-01-19T06:41:28Z | - |
| dc.date.available | 2022-01-19T06:41:28Z | - |
| dc.date.created | 2022-01-19 | - |
| dc.date.issued | 2018-04 | - |
| dc.identifier.issn | 1523-7060 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83307 | - |
| dc.description.abstract | WS9326H (1), a new cyclic peptide, was isolated from a mudflat-derived Streptomyces strain. Based on analysis by 1D/2D NMR, UV spectroscopy, and mass spectrometry, compound 1 was determined to have the gross structure of a cyclic heptapeptide bearing an unprecedented pyrazolone ring connected to a D-arabinitol via an amide bond. The absolute configuration of 1 was established by multistep chemical derivatizations, comprehensive NMR, and LC/MS analyses of the derivatives and quantum mechanics-based computational methods. WS9326H (1) displayed significant antiangiogenesis activity. | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | AMER CHEMICAL SOC | - |
| dc.relation.isPartOf | ORGANIC LETTERS | - |
| dc.title | WS9326H, an Antiangiogenic Pyrazolone-Bearing Peptide from an Intertidal Mudflat Actinomycete | - |
| dc.type | Article | - |
| dc.type.rims | ART | - |
| dc.description.journalClass | 1 | - |
| dc.identifier.wosid | 000429886900072 | - |
| dc.identifier.doi | 10.1021/acs.orglett.8b00546 | - |
| dc.identifier.bibliographicCitation | ORGANIC LETTERS, v.20, no.7, pp.1999 - 2002 | - |
| dc.description.isOpenAccess | N | - |
| dc.identifier.scopusid | 2-s2.0-85045151687 | - |
| dc.citation.endPage | 2002 | - |
| dc.citation.startPage | 1999 | - |
| dc.citation.title | ORGANIC LETTERS | - |
| dc.citation.volume | 20 | - |
| dc.citation.number | 7 | - |
| dc.contributor.affiliatedAuthor | Bae, Munhyung | - |
| dc.type.docType | Article | - |
| dc.subject.keywordPlus | STREPTOMYCES SP | - |
| dc.subject.keywordPlus | ANGIOGENESIS INHIBITORS | - |
| dc.subject.keywordPlus | TACHYKININ ANTAGONIST | - |
| dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
| dc.subject.keywordPlus | AMINO-ACIDS | - |
| dc.subject.keywordPlus | STEREOCHEMISTRY | - |
| dc.subject.keywordPlus | CONFIGURATION | - |
| dc.subject.keywordPlus | DERIVATIVES | - |
| dc.subject.keywordPlus | SCAFFOLD | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
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Related Researcher
- Bae, Munhyung
- Pharmacy (Dept.of Pharmacy)