Separacenes A-D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Munhyung | - |
dc.contributor.author | Kim, Heegyu | - |
dc.contributor.author | Shin, Yoonho | - |
dc.contributor.author | Kim, Byung Yong | - |
dc.contributor.author | Lee, Sang Kook | - |
dc.contributor.author | Oh, Ki-Bong | - |
dc.contributor.author | Shin, Jongheon | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.date.accessioned | 2022-01-19T06:41:56Z | - |
dc.date.available | 2022-01-19T06:41:56Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83315 | - |
dc.description.abstract | Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C-D (3-4) possess a triene moiety between two diol substructures. Separacenes A-D each contain a terminal olefinic methylene. Separacene A displayed inhibitory activity against Candida albicans isocitrate lyase and weak cytotoxicity against both the colon carcinoma cell line HCT-116 and the lung cancer cell line A549. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MARINE DRUGS | - |
dc.title | Separacenes A-D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp. | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000330521300013 | - |
dc.identifier.doi | 10.3390/md11082882 | - |
dc.identifier.bibliographicCitation | MARINE DRUGS, v.11, no.8, pp.2882 - 2893 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84883787583 | - |
dc.citation.endPage | 2893 | - |
dc.citation.startPage | 2882 | - |
dc.citation.title | MARINE DRUGS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Bae, Munhyung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | marine actinomycete | - |
dc.subject.keywordAuthor | polyene polyol | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | isocitrate lyase | - |
dc.subject.keywordPlus | DRUG DISCOVERY | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.